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Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
VTT Technical Research Centre of Finland, Tampere, Finland; Combinostics Oy, Tampere, Finland.
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2017 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 60, no 4, p. 1387-1395Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear.

OBJECTIVE: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI.

METHODS: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aβ42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only.

RESULTS: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results.

CONCLUSIONS: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.

Place, publisher, year, edition, pages
IOS Press, 2017. Vol. 60, no 4, p. 1387-1395
Keywords [en]
Alcohol consumption, Alzheimer’s disease, amyloid-β (1–42), cerebrospinal fluid, cognitive reserve, exercise, hippocampus, lifestyle, mild cognitive impairment
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-74039DOI: 10.3233/JAD-170039ISI: 000414612200017PubMedID: 29036813Scopus ID: 2-s2.0-85033561388OAI: oai:DiVA.org:oru-74039DiVA, id: diva2:1313784
Funder
EU, FP7, Seventh Framework Programme, 601055 FP7-224328-PredictAD
Note

Funding Agency:

European Commission as part of the 5th Framework Program  QLK-6-CT-2002-02455

Available from: 2019-05-06 Created: 2019-05-06 Last updated: 2019-06-18Bibliographically approved

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