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Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer's Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study
Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Stockholm; Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Stockholm.
Department of Medicine, Division of Hematology, Karolinska Institutet, Huddinge, Stockholm.
Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Stockholm.
Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Stockholm.ORCID iD: 0000-0001-6863-6679
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2015 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 48, no 3, p. 805-812Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: ω3 fatty acids (ω3 FAs) may slow the rate of decline in cognitive performance in mild forms of cognitive impairment and Alzheimer's disease (AD). However, the relationship between changes of plasma ω3 FA levels and cognitive performance, as well as effects of gender, are poorly known.

OBJECTIVE: To study the effect of 6-month administration of DHA-rich ω3 FA supplementation on plasma FA profiles in patients with mild to moderate AD in relation to cognitive performance and gender. This investigation is part of the OmegAD Study.

METHODS: 174 AD patients (74 ± 9 years) were randomized to a daily intake of 2.3 g ω3 FA or placebo for 6 months; subsequently all received the ω3 FA preparation for the next 6 months. Baseline as well as changes in plasma levels of the main ω3 FAs in 165 patients, while receiving ω3 FA supplementation for 6 months, were analyzed for association to cognitive performance (assessed by ADAS-cog and MMSE scores) as well as to gender.

RESULTS: Preservation of cognitive functioning, assessed by ADAS-cog or its sub-items (but not MMSE) scores, was significantly associated to increasing plasma ω3 FA levels over time. Thus, the higher ω3 FA plasma levels rose, the lower was the rate of cognitive deterioration. This effect was not related to gender; since although females displayed higher ω3 FA plasma levels than did males after 6 months of supplementation, this difference disappeared when adjusted for body weight.

CONCLUSIONS: Since our study suggests dose-response relationships between plasma levels of ω3 FA and preservation of cognition, future ω3 FA trials in patients with mild AD should consider exploring graded (and body weight adjusted) doses of ω3 FA.

Place, publisher, year, edition, pages
IOS Press, 2015. Vol. 48, no 3, p. 805-812
Keywords [en]
Alzheimer’s disease, ClinicalTrials.gov identifier: NCT00211159, DHA, EPA, cognition, gender, ω3 fatty acids
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-74049DOI: 10.3233/JAD-150102ISI: 000362958800022PubMedID: 26402079Scopus ID: 2-s2.0-84943745395OAI: oai:DiVA.org:oru-74049DiVA, id: diva2:1313959
Note

Funding agencies:

Stockholm County Council and Karolinska Institutet, Medical Research Council (19X-05991, 71XS-13135, 072194)

Funds of Capio

Demensförbundet

Gamla Tjänarinnor

Gun och Bertil Stohnes Stiftelse

Swedish Society of Physicians

Lion's Sweden

Pronova Biocare A/S, Lysaker, Norway

Available from: 2019-05-07 Created: 2019-05-07 Last updated: 2019-06-18Bibliographically approved

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Freund-Levi, Yvonne

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