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Agitation in dementia: relation to core cerebrospinal fluid biomarker levels
Division of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Center for Alzheimer Research, Division for Neurogeriatrics, Department of Neurobiology, Caring Sciences and Society (NVS), Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nev., USA.
Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.
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2014 (English)In: Dementia and geriatric cognitive disorders extra, E-ISSN 1664-5464, Vol. 4, no 2, p. 335-43Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The objective of this study was to examine the associations of agitation with the cerebrospinal fluid dementia biomarkers total-tau (T-tau), phosphorylated-tau (P-tau) and Aβ1-42.

METHODS: One hundred patients (mean age ± SD, 78.6 ± 7.5 years) with dementia and neuropsychiatric symptoms, of whom 67% were female, were included. Agitation was measured using the Cohen-Mansfield Agitation Inventory (CMAI; 46.5 ± 11.8 points).

RESULTS: Total CMAI correlated with T-tau [rs (31) = 0.36, p = 0.04] and P-tau [rs (31) = 0.35, p = 0.05] in patients with Alzheimer's disease (AD; n = 33) but not in the total dementia population (n = 95).

CONCLUSIONS: Our results suggest that tau-mediated pathology including neurofibrillary tangles and the intensity of the disease process might be associated with agitation in AD.

Place, publisher, year, edition, pages
S. Karger, 2014. Vol. 4, no 2, p. 335-43
Keywords [en]
Agitation, Behavioral and psychological symptoms in dementia (BPSD), CMAI, Cerebrospinal fluid (CSF), Dementia, Dementia biomarkers, Neurofibrillary tangles
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-74052DOI: 10.1159/000363500PubMedID: 25298777OAI: oai:DiVA.org:oru-74052DiVA, id: diva2:1313963
Available from: 2019-05-07 Created: 2019-05-07 Last updated: 2019-05-23Bibliographically approved

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Freund-Levi, Yvonne

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