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Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study
Divisions of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Stockholm.ORCID iD: 0000-0001-6863-6679
Divisions of Neurodegeneration, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Stockholm.
Divisions of Neurodegeneration, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Stockholm.
Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
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2009 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 27, no 5, p. 481-490Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: omega-3 fatty acids (omega-3 FAs) found in dietary fish or fish oils are anti-inflammatory agents that may influence Alzheimer's disease (AD).

OBJECTIVE: To study the effects of dietary omega-3 FA supplementation on inflammatory markers in cerebrospinal fluid (CSF) and plasma from patients with mild to moderate AD.

METHODS: Thirty-five patients (70.3 +/- 8.2 years) were randomized to a daily intake of 2.3 g omega-3 FAs or placebo for 6 months. The inflammatory markers interleukin (IL)-6, tumour necrosis factor-alpha and soluble interleukin-1 receptor type II (sIL-1RII) were analysed in CSF and plasma at baseline and at 6 months. The AD markers tau-protein, hyperphosphorylated tau-protein and beta-amyloid (Abeta(1-42)) were assessed in CSF. High-sensitivity C-reactive protein was assessed in plasma. A possible relation to the APOE genotype was investigated.

RESULTS: There was no significant treatment effect of omega-3 FAs on inflammatory and AD biomarkers in CSF or on inflammatory markers in plasma, nor was there any relation with APOE. A significant correlation was observed at baseline between sIL-1RII and Abeta(1-42) levels in CSF.

CONCLUSIONS: Treatment of AD patients with omega-3 FAs for 6 months did not influence inflammatory or biomarkers in CSF or plasma. The correlation between sIL-1RII and Abeta(1-42) may reflect the reciprocal interactions between IL-1 and Abeta peptides.

Place, publisher, year, edition, pages
S. Karger, 2009. Vol. 27, no 5, p. 481-490
Keywords [en]
Alzheimer's disease, Inflammation, Cerebrospinal fluid, omega-3 fatty acids, Cytokines
National Category
Geriatrics Neurology Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-74159DOI: 10.1159/000218081ISI: 000266098300011PubMedID: 19439966Scopus ID: 2-s2.0-65549164405OAI: oai:DiVA.org:oru-74159DiVA, id: diva2:1314556
Funder
The Dementia Association - The National Association for the Rights of the Demented
Note

Funding Agencies:

Stockholm County Council and Karolinska Institutet  

Funds of Capio  

Stiftelsen Gamla Tjänarinnor  

Swedish Alzheimer Foundation  

Odd Fellow  

Swedish Nutrition Foundation  

Gun och Bertil Stohnes Stiftelse  

Swedish Society of Physicians and Lion's Sweden  

Pronova Biocare A/S, Lysaker, Norway 

Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-05-14Bibliographically approved

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Freund-Levi, Yvonne

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