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Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study
Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.ORCID iD: 0000-0001-6863-6679
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Divisions of Geriatrics, Uppsala University Hospital, Uppsala, Sweden.
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2009 (English)In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415, Vol. 57, no 1, p. 11-17Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4).

DESIGN: Randomized, double-blind, placebo-controlled trial.

SETTING: Specialist memory clinics in the Stockholm catchment area.

PARTICIPANTS: Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD.

INTERVENTION: Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months.

MEASUREMENTS: Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver.

RESULTS: Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up.

CONCLUSION: A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain.

Place, publisher, year, edition, pages
Blackwell Publishing, 2009. Vol. 57, no 1, p. 11-17
Keywords [en]
Omega-3 fatty acids, weight gain, Alzheimer's disease, dementia, appetite, nutrition, APOE
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:oru:diva-74160DOI: 10.1111/j.1532-5415.2008.02055.xISI: 000262130600002PubMedID: 19054188Scopus ID: 2-s2.0-58149234260OAI: oai:DiVA.org:oru-74160DiVA, id: diva2:1314557
Funder
Stockholm County CouncilThe Karolinska Institutet's Research FoundationThe Dementia Association - The National Association for the Rights of the DementedStiftelsen Gamla TjänarinnorSwedish Nutrition Foundation (SNF)Gun och Bertil Stohnes Stiftelse
Note

Funding Agencies:

Funds of Capio

Swedish Alzheimer Foundation 

Odd Fellow

Swedish Society of Physicians  

Lion's Sweden 

Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-05-17Bibliographically approved

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Freund-Levi, Yvonne

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