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Staphylococcus aureus in chronic rhinosinusitis: the effect on the epithelial chloride channel (cystic fibrosis transmembrane conductance regulator, CFTR) and the epithelial sodium channel (ENaC) physiology
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Otolaryngology.
Department of Microbiology and Immunology, Institution of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden.
Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden; Department of Medical Education, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
2019 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 139, no 7, p. 652-658Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Chronic rhinosinusitis (CRS) is an inflammatory disease of the nose and the paranasal sinuses, often associated with an infection by Staphylococcus aureus (S. aureus). Disturbance in the function of ion channels is regarded as an etiological factor for pathogenesis of CRS.

AIMS: The study aims to measure the mRNA expression of the ENaC and CFTR ion channels in nasal epithelial cells (NECs) and to investigate the effect of both the budesonide and S. aureus on these ion channels.

MATERIALS AND METHOD: NECs biopsies obtained from healthy volunteers and patients with CRS. NECs were infected with S. aureus strains and/or budesonide to study the mRNA expression levels of the ENaC and CFTR ion channels.

RESULTS: The mRNA expression level of CFTR was increased while that of ENaC was decreased. S. aureus infection and budesonide treatment induced a significant modulation of ENaC and CFTR ion channels expression.

CONCLUSION: The CFTR and ENaC ion channel physiology are of importance in the pathogenesis of CRS. Exposure to S. aureus infection and treatment with budesonide modulated the mRNA expression of CFTR and ENaC ion channels.

SIGNIFICANCE: Better understanding of the pathophysiology of CRS.

Place, publisher, year, edition, pages
Taylor & Francis, 2019. Vol. 139, no 7, p. 652-658
Keywords [en]
Chronic rhinosinusitis, ENaC and CFTR ion channel expression
National Category
Immunology
Identifiers
URN: urn:nbn:se:oru:diva-74196DOI: 10.1080/00016489.2019.1603513ISI: 000482254100019PubMedID: 31050570Scopus ID: 2-s2.0-8506538951OAI: oai:DiVA.org:oru-74196DiVA, id: diva2:1315276
Note

Funding Agencies:

Research Committee in Region Örebro County  

Foundation for Medical Research at the University Hospital Örebro (Örebro, Sweden) 

Available from: 2019-05-13 Created: 2019-05-13 Last updated: 2019-09-04Bibliographically approved

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Saber, Amanj

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