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The acute transcriptional response to resistance exercise: impact of age and contraction mode
Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, UK.
Living Systems Institute, University of Exeter, Exeter, UK.
MRC ‐ ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK.
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
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2019 (English)In: Aging, ISSN 1945-4589, E-ISSN 1945-4589, Vol. 11, no 7, p. 2111-2126Article in journal (Refereed) Published
Abstract [en]

Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We used transcriptomics to compare age-related molecular responses to acute CON and ECC exercise. Eight young (21 +/- 1 y) and eight older (70 +/- 1 y) exercise-naive male volunteers had vastus lateralis biopsies collected at baseline and 5 h post unilateral CON and contralateral ECC exercise. RNA was subjected to next-generation sequencing and differentially expressed (DE) genes tested for pathway enrichment using Gene Ontology (GO). The young transcriptional response to CON and ECC was highly similar and older adults displayed moderate contraction-specific profiles, with no GO enrichment. Age-specific responses to ECC revealed 104 DE genes unique to young, and 170 DE genes in older muscle, with no GO enrichment. Following CON, 15 DE genes were young muscle-specific, whereas older muscle uniquely expressed 147 up-regulated genes enriched for cell adhesion and blood vessel development, and 28 down-regulated genes involved in mitochondria! respiration, amino acid and lipid metabolism. Thus, older age is associated with contraction-specific regulation often without clear functional relevance, perhaps reflecting a degree of stochastic age-related dysregulation.

Place, publisher, year, edition, pages
Impact Journals LLC , 2019. Vol. 11, no 7, p. 2111-2126
Keywords [en]
concentric, eccentric, sarcopenia, transcriptome
National Category
Geriatrics Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-74285DOI: 10.18632/101904ISI: 000465959700017PubMedID: 30996129Scopus ID: 2-s2.0-85064525157OAI: oai:DiVA.org:oru-74285DiVA, id: diva2:1315869
Funder
Wellcome trust, WT105618MA
Note

Funding Agencies:

Bournemouth University

EPSRC/BBSRC Innovation Fellowship  EP/S001352/1 

Medical Research Council  MR/P021220/1  MR/K00414X/1 

Arthritis Research UK  19891 

National Institute for Health Research, Nottingham Biomedical Research Centre  

Biotechnology and Biological Sciences Research Council  BB/N015894/1  BB/J014400/1  BB/M009122/1 

Swedish Research Council for Sport Science  2016/125  2017/143 

Available from: 2019-05-15 Created: 2019-05-15 Last updated: 2019-05-15Bibliographically approved

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Kadi, Fawzi

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