oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Incidence of Childhood Thyrotoxicosis Is Increasing in Both Girls and Boys in Sweden
Örebro University, School of Medical Sciences. Department of Paediatrics.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Paediatrics, School of Medical Sciences, Örebro University, Örebro, Sweden; University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-5292-4913
Department of Paediatrics, Central Hospital, Karlstad, Sweden.
Department of Paediatrics, Västerås Hospital, Västerås, Sweden.
Show others and affiliations
2019 (English)In: Hormone Research in Paediatrics, ISSN 1663-2818, E-ISSN 1663-2826, Vol. 91, no 3, p. 195-202Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: We found an increase in the incidence rate (IR) of childhood thyrotoxicosis (CT) during the 1990s in central Sweden. The optimal treatment method for CT is a subject that is still debated upon.

OBJECTIVES: To investigate whether the increase in IR of CT in Sweden persists and to study the treatment outcome.

METHOD: Children <16 years of age diagnosed with CT during 2000-2009 and living in 1 of 5 counties in central Sweden were identified retrospectively using hospital registers. Data on clinical and biochemical characteristics and outcomes of treatment were collected from medical records. The corresponding data from 1990 to 1999 were pooled with the new data.

RESULTS: In total, 113 children were diagnosed with CT during 1990-2009 in the study area. The overall IR was 2.2/100,000 person-years (95% CI 1.2-2.5/100,000 person-years). The IR was significantly higher during 2000-2009 than during 1990-1999 (2.8/100,000 [2.2-3.6] vs. 1.6/100,000 person-years [1.2-2.2], p = 0.006). The increase was significant for both sexes. Seventy percent of the patients who completed the planned initial treatment with antithyroid drugs (ATDs) and were not lost to follow-up relapsed within 3 years. Boys tended to relapse earlier than girls (6.0 months after drug withdrawal [95% CI 1.9-10.0] vs. 12.0 months [95% CI 6.8-17.3], p = 0.074).

CONCLUSIONS: The IR of CT is increasing in both girls and boys. Relapse rate after withdrawal of ATD treatment is 70%. Boys tend to relapse earlier than girls, and this needs to be further investigated.

Place, publisher, year, edition, pages
S. Karger, 2019. Vol. 91, no 3, p. 195-202
Keywords [en]
Children, Hyperthyroidism, Incidence rate, Relapse, Thyrotoxicosis
National Category
Pediatrics Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-74317DOI: 10.1159/000500265ISI: 000476517300005PubMedID: 31096231Scopus ID: 2-s2.0-85065962578OAI: oai:DiVA.org:oru-74317DiVA, id: diva2:1316709
Note

Funding Agency:

ALF funding at Region Örebro County, Sweden

Available from: 2019-05-20 Created: 2019-05-20 Last updated: 2019-08-12Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Rodanaki, MariaLodefalk, Maria

Search in DiVA

By author/editor
Rodanaki, MariaLodefalk, Maria
By organisation
School of Medical SciencesÖrebro University Hospital
In the same journal
Hormone Research in Paediatrics
PediatricsEndocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 30 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf