oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Intrapulmonary administration of insulin to healthy volunteers
Department of Internal Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.ORCID iD: 0000-0003-1025-1682
Department of Internal Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
1996 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 240, no 2, p. 93-98Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To study the biological effects of nebulized insulin, administered intrapulmonary, to healthy volunteers.

DESIGN: A double-blind, randomized, controlled intervention study.

SETTING: The department of Internal Medicine, University Hospital, Linköping, Sweden.

SUBJECTS: Eight healthy, non-smoking volunteers, with a mean age of 28 (range 22 to 56) years.

INTERVENTIONS: Regular human insulin 100 U mL-1 (Actrapid) or 0.9% saline was given randomly as an oral inhalation. Insulin was given in three different doses (40, 80 and 160 U). Aerosol was generated by a new jet nebulizer.

MAIN OUTCOME MEASURES: Blood glucose, serum insulin, and serum C-peptide.

RESULTS: After the 160 U insulin dose the blood glucose concentration (mean +/- SE) fell from 4.3 +/- 0.2 to 2.8 +/- 0.2 mmol L-1 (P < 0.001), concomitant with an increase in mean serum insulin concentrations, rising from 9.5 +/- 1.5 to 26.1 +/- 2.5 mU L-1 (P < 0.001). Serum C-peptide concentrations simultaneously decreased from 0.48 +/- 0.03 to 0.12 +/- 0.02 mmol L-1 (P < 0.001). All changes were dose dependent. No adverse reactions were noted and no significant changes in lung function tests.

CONCLUSIONS: Intrapulmonary insulin administration to healthy subjects can induce a significant hypoglycaemia and cause a clinically relevant increase in serum insulin concentrations. If similar results can be obtained when administering insulin to diabetic subjects, this insulin administration route can be a future complement to certain groups of patients.

Place, publisher, year, edition, pages
Blackwell Science Ltd. , 1996. Vol. 240, no 2, p. 93-98
Keywords [en]
aerosol, C-peptide, insulin, nebulization, oral inhalation
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-74503DOI: 10.1046/j.1365-2796.1996.502836000.xISI: A1996VG35700006PubMedID: 8810935Scopus ID: 2-s2.0-0029847551OAI: oai:DiVA.org:oru-74503DiVA, id: diva2:1319152
Available from: 2019-05-29 Created: 2019-05-29 Last updated: 2019-06-11Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Jendle, Johan

Search in DiVA

By author/editor
Jendle, Johan
In the same journal
Journal of Internal Medicine
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 27 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf