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Subpopulations of variants resistant to imipenem in Pseudomonas aeruginosa
Department of Clinical Bacteriology, University Hospital, Linköping, Sweden.
Department of Clinical Bacteriology, University Hospital, Linköping, Sweden.
Department of Clinical Bacteriology, University Hospital, Linköping, Sweden.ORCID iD: 0000-0003-1025-1682
1988 (English)In: Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, E-ISSN 1460-2091, Vol. 22, no 5, p. 643-649Article in journal (Refereed) Published
Abstract [en]

Selection and regrowth of resistant variants, which were present in low frequencies in the initial inoculum, was seen when large inocula of Pseudomonas aeruginosa were incubated with imipenem. The selective growth of resistant variants resulted in an inoculum effect, and an increase in MIC with longer incubation. When large inocula taken from strains that had been classified as sensitive in conventional MIC determinations were incubated with 4, 8 and 16 mg/l imipenem, 62%, 24% and 10%, respectively, of the strains regrew. None of the resistant variants thereby selected showed cross resistance to other beta-lactam antibiotics or aminoglycosides. In vitro evaluation of regrowth of resistant variants may be justified when choosing imipenem for therapy in the treatment of serious P. aeruginosa infections.

Place, publisher, year, edition, pages
Oxford University Press, 1988. Vol. 22, no 5, p. 643-649
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-74500DOI: 10.1093/jac/22.5.643ISI: A1988R092700011PubMedID: 3145266Scopus ID: 2-s2.0-0024160801OAI: oai:DiVA.org:oru-74500DiVA, id: diva2:1319155
Available from: 2019-05-29 Created: 2019-05-29 Last updated: 2019-06-10Bibliographically approved

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