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Serum untargeted lipidomic profiling reveals dysfunction of phospholipid metabolism in subclinical coronary artery disease
Örebro University, School of Medical Sciences. Department of Cardiology.ORCID iD: 0000-0002-2957-9904
Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-7173-5579
Örebro University, School of Science and Technology. (Man-Technology-Environment Research Centre)ORCID iD: 0000-0002-4382-4355
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2019 (English)In: Vascular Health and Risk Management, ISSN 1176-6344, E-ISSN 1178-2048, Vol. 15, p. 123-135Article in journal (Refereed) Published
Abstract [en]

Purpose: Disturbed metabolism of cholesterol and triacylglycerols (TGs) carries increased risk for coronary artery calcification (CAC). However, the exact relationship between individual lipid species and CAC remains unclear. The aim of this study was to identify disturbances in lipid profiles involved in the calcification process, in an attempt to propose potential biomarker candidates.

Patients and methods: We studied 70 patients at intermediate risk for coronary artery disease who had undergone coronary calcification assessment using computed tomography and Agatston coronary artery calcium score (CACS). Patients were divided into three groups: with no coronary calcification (NCC; CACS: 0; n=26), mild coronary calcification (MCC; CACS: 1-250; n=27), or severe coronary calcification (SCC; CACS: >250; n=17). Patients' serum samples were analyzed using liquid chromatography-mass spectrometry in an untargeted lipidomics approach.

Results: We identified 103 lipids within the glycerolipid, glycerophospholipid, sphingolipid, and sterol lipid classes. After false discovery rate correction, phosphatidylcholine (PC)(16:0/20:4) in higher levels and PC(18:2/18:2), PC(36:3), and phosphatidylethanolamine(20:0/18:2) in lower levels were identified as correlates with SCC compared to NCC. There were no significant differences in the levels of individual TGs between the three groups; however, clustering the lipid profiles showed a trend for higher levels of saturated and monounsaturated TGs in SCC compared to NCC. There was also a trend for lower TG (49:2), TG(51:1), TG(54:5), and TG(56:8) levels in SCC compared to MCC.

Conclusion: In this study we investigated the lipidome of patients with coronary calcification. Our results suggest that the calcification process may be associated with dysfunction in autophagy. The lipidomic biomarkers revealed in this study may aid in better assessment of patients with subclinical coronary artery disease.

Place, publisher, year, edition, pages
DOVE Medical Press Ltd. , 2019. Vol. 15, p. 123-135
Keywords [en]
coronary artery calcification, coronary artery calcium score, lipidomics, triacylglycerol, lipids, atherosclerosis, autophagy
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-74648DOI: 10.2147/VHRM.S202344ISI: 000468547500001OAI: oai:DiVA.org:oru-74648DiVA, id: diva2:1321926
Funder
Swedish Heart Lung FoundationAvailable from: 2019-06-10 Created: 2019-06-10 Last updated: 2019-06-10Bibliographically approved

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Djekic, DemirRepsilber, DirkHyötyläinen, Tuulia

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