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Skeletal muscle characteristics of long-term endurance- and strength trained athletes versus healthy controls: A cross-sectional comparison
Örebro University, School of Health Sciences.
2017 (English)Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
Abstract [en]

Introduction: It is well-established that regular exercise training alters the characteristics of skeletal muscle. Thus, this cross-sectional study reports the skeletal muscle characteristics of long-term trained (>15 years) endurance- (ET) and strength (ST) athletes compared with healthy controls (C). The aim was to compare fiber cross-sectional area (CSA), citrate synthase activity (CS), myonuclei content and myosin heavy chain (MyHC)-proportions between groups.

Materials and methods: A total of twenty-three male subjects (41.7 ± 4.2 years) qualified for the study based on self-reported activity and performance testing. Performance testing consisted of a VO2peak test and a maximal isokinetic knee extension test. Skeletal muscle characteristics were assessed from muscle biopsies using immunohistochemistry, an enzymatic activity-assay and a polyacrylamide separation gel. Muscle biopsies were taken from the m. vastus lateralis at rest.

Results: ST men had higher myonuclei content and a larger fiber CSA compared with C. ET subjects demonstrated a higher CS-activity compared with both C and ST. However, no differences were found in CS-activity between C and ST subjects. Finally, ET subjects demonstrated a significantly higher proportion of the MyHC I-isoform compared with C and ST. However, C subjects displayed a higher proportion of MyHC IIx compared with ET and ST.

Conclusion:We show that endurance-trained individuals display a great oxidative capacity, demonstrated by enhanced CS-activity, higher proportion of slow myosin heavy chain content and greater VO2peak. Additionally, we conclude that the greater strength output in strength-trained individuals compared with control is related to larger fiber CSA and higher myonuclei content.

Place, publisher, year, edition, pages
2017. , p. 32
Keywords [en]
Physiology, myonuclear content, hypertrophy, mitochondrial biogenesis, VO2
National Category
Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:oru:diva-74832OAI: oai:DiVA.org:oru-74832DiVA, id: diva2:1331863
Subject / course
Sports Science
Examiners
Available from: 2019-07-05 Created: 2019-06-27 Last updated: 2019-07-05Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf