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Incidence and prognosis of the takotsubo syndrome compared to acute myocardial infarction
Sahlgrenska Academy, University of Gothenburg, Dept of Molecular & ClinicalMedicine/Cardiology, Gothenburg, Sweden.
Sahlgrenska Academy, University of Gothenburg, Dept of Molecular & ClinicalMedicine/Cardiology, Gothenburg, Sweden.
Sahlgrenska Academy, University of Gothenburg, Dept of Molecular & ClinicalMedicine/Cardiology, Gothenburg, Sweden.
Sahlgrenska Academy, University of Gothenburg, Dept of Molecular & ClinicalMedicine/Cardiology, Gothenburg, Sweden.
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2019 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 21, p. 267-267Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background: Takotsubo syndrome (TS) is a potentially life-threatening acute cardiac syndrome with a clinical presentation very similar to myocardial infarction (MI) and for which the natural history, management and outcome remain incompletely understood.

Purpose: The aims of this study were to assess the relative short- and long-term mortality risk of TS , ST-elevation MI (STEMI) and non STEMI (NSTEMI) and to identify predictors of in-hospital complications and poor prognosis in patients with TS.

Methods: Using the nationwide Swedish Angiography and Angioplasty Registry (SCAAR) we identified almost all (n=117,720) patients who underwent coronary angiography due to TS (N=2,898 [2.5%]), STEMI (N=48,493 [41.2%]) or NSTEMI (N=66,329 [56.3%]) in Sweden between January 2009 and February 2018.

Results: Patients with TS were more often women as compared with patients with STEMI or NSTEMI. TS was associated with unadjusted and adjusted 30-day mortality risks lower than STEMI (adjusted hazard ratio [adjHR] 0.60, 95% confidence interval [CI]0.48-0.76, p<0.001), but higher than NSTEMI (adjHR 2.70, 95% CI 2.14-3.41, p<0.001). Compared to STEMI, TS was associated with similar risk of acute heart failure (adjHR 1.26, 95% CI 0.91–1.76, p=0.16) but lower risk of cardio-genic shock (adjHR 0.55, 95% CI 0.34–0.89, p=0.02). The relative 30-day mortality risk for TS versus STEMI and NSTEMI was higher for smokers than non-smokers (adjusted pinteractionSTEMI=0.01 and pinteractionNSTEMI=0.01).

Conclusion: Thirty-day mortality in TS was higher than in NSTEMI but lower than STEMI, despite a similar risk of acute heart failure in TS and STEMI. Among patients with TS, smoking was an independent predictor of mortality

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 21, p. 267-267
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-74733ISI: 000468990703054OAI: oai:DiVA.org:oru-74733DiVA, id: diva2:1338324
Available from: 2019-07-22 Created: 2019-07-22 Last updated: 2019-07-22Bibliographically approved

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Fröbert, Ole

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