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Uppsala Longitudinal Adolescent Depression Study (ULADS)
Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden.
Örebro University, School of Health Sciences. University Health Care Research Centre.ORCID iD: 0000-0001-8433-6529
Department of Public Health and Caring Sciences, Child Health and Parenting (CHAP), Uppsala University, Uppsala, Sweden.
Örebro University, School of Health Sciences. Örebro University Hospital. University Health Care Research Centre.
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2019 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 9, no 3, article id e024939Article in journal (Refereed) Published
Abstract [en]

Purpose: To present the Uppsala Longitudinal Adolescent Depression Study, initiated in Uppsala, Sweden, in the early 1990s. The initial aim of this epidemiological investigation was to study the prevalence, characteristics and correlates of adolescent depression, and has subsequently expanded to include a broad range of social, economic and health-related long-term outcomes and cost-of-illness analyses.

Participants: The source population was first-year students (aged 16-17) in upper-secondary schools in Uppsala during 1991-1992, of which 2300 (93%) were screened for depression. Adolescents with positive screening and sex/age-matched peers were invited to a comprehensive assessment. A total of 631 adolescents (78% females) completed this assessment, and 409 subsequently completed a 15year follow-up assessment. At both occasions, extensive information was collected on mental disorders, personality and psychosocial situation. Detailed social, economic and health-related data from 1993 onwards have recently been obtained from the Swedish national registries for 576 of the original participants and an age-matched reference population (N=200 000).

Findings to date: The adolescent lifetime prevalence of a major depressive episode was estimated to be 11.4%. Recurrence in young adulthood was reported by the majority, with a particularly poor prognosis for those with a persistent depressive disorder or multiple somatic symptoms. Adolescent depression was also associated with an increased risk of other adversities in adulthood, including additional mental health conditions, low educational attainment and problems related to intimate relationships.

Future plans: Longitudinal studies of adolescent depression are rare and must be responsibly managed and utilised. We therefore intend to follow the cohort continuously by means of registries. Currently, the participants are approaching mid-adulthood. At this stage, we are focusing on the overall long-term burden of adolescent depression. For this purpose, the research group has incorporated expertise in health economics. We would also welcome extended collaboration with researchers managing similar datasets.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2019. Vol. 9, no 3, article id e024939
National Category
General Practice Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-75243DOI: 10.1136/bmjopen-2018-024939ISI: 000471144900167PubMedID: 30826765Scopus ID: 2-s2.0-85062413050OAI: oai:DiVA.org:oru-75243DiVA, id: diva2:1338990
Funder
Swedish Research Council, 2014-10092Forte, Swedish Research Council for Health, Working Life and Welfare
Note

Funding Agencies:

Uppsala-Orebro Regional Research Council  RFR-738411  RFR-652841 

Uppsala County Council's Funds for Clinical Research  LUL-713161 

Medical Training and Research Agreement Funds (ALF) from Uppsala University Hospital 

Märta and Nicke Nasvell Foundation  

Clas Groschinsky Memorial Fund  

Söderström-Königska Foundation  

Foundation in Memory of Professor Bror Gadelius 

Available from: 2019-07-25 Created: 2019-07-25 Last updated: 2019-07-25Bibliographically approved

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Philipsson, AnnaHagberg, LarsMöller, Margareta

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