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Chromogranin-A Expression as a Novel Biomarker for Early Diagnosis of Colon Cancer Patients
Örebro University, School of Medical Sciences. Centre for Systems Biology, Soochow University, Suzhou, China.ORCID iD: 0000-0001-5963-9261
Örebro University, School of Medical Sciences.
Centre for Systems Biology, Soochow University, Suzhou, China.
Department of Oncology and Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
2019 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 20, no 12, article id 2919Article in journal (Refereed) Published
Abstract [en]

Colon cancer is one of the major causes of cancer death worldwide. The five-year survival rate for the early-stage patients is more than 90%, and only around 10% for the later stages. Moreover, half of the colon cancer patients have been clinically diagnosed at the later stages. It is; therefore, of importance to enhance the ability for the early diagnosis of colon cancer. Taking advantages from our previous studies, there are several potential biomarkers which have been associated with the early diagnosis of the colon cancer. In order to investigate these early diagnostic biomarkers for colon cancer, human chromogranin-A (CHGA) was further analyzed among the most powerful diagnostic biomarkers. In this study, we used a logistic regression-based meta-analysis to clarify associations of CHGA expression with colon cancer diagnosis. Both healthy populations and the normal mucosa from the colon cancer patients were selected as the double normal controls. The results showed decreased expression of CHGA in the early stages of colon cancer as compared to the normal controls. The decline of CHGA expression in the early stages of colon cancer is probably a new diagnostic biomarker for colon cancer diagnosis with high predicting possibility and verification performance. We have also compared the diagnostic powers of CHGA expression with the typical oncogene KRAS, classic tumor suppressor TP53, and well-known cellular proliferation index MKI67, and the CHGA showed stronger ability to predict early diagnosis for colon cancer than these other cancer biomarkers. In the protein-protein interaction (PPI) network, CHGA was revealed to share some common pathways with KRAS and TP53. CHGA might be considered as a novel, promising, and powerful biomarker for early diagnosis of colon cancer.

Place, publisher, year, edition, pages
MDPI , 2019. Vol. 20, no 12, article id 2919
Keywords [en]
CHGA, colon cancer, biomarker, early diagnosis, logistic regression, meta-analysis, PPI
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:oru:diva-75234DOI: 10.3390/ijms20122919ISI: 000473756000069PubMedID: 31207989Scopus ID: 2-s2.0-85068403124OAI: oai:DiVA.org:oru-75234DiVA, id: diva2:1339069
Funder
Swedish Cancer SocietySwedish Research CouncilAvailable from: 2019-07-25 Created: 2019-07-25 Last updated: 2019-07-25Bibliographically approved

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Xueli, ZhangZhang, Hong

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