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Electroconvulsive therapy in bipolar depression: effectiveness and prognostic factors
Örebro University, School of Medical Sciences. University Health Care Research Centre.
Örebro University, School of Medical Sciences. University Health Care Research Centre.ORCID iD: 0000-0002-3587-6075
Örebro University, School of Medical Sciences. (Clinical Epidemiology and Biostatistics)
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway: Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
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2019 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVE: Electroconvulsive therapy (ECT) is used in patients with severe forms of bipolar depression. ECT is effective but not all patients respond. The aim of this study was to determine prognostic factors for response to ECT in patients hospitalized for bipolar depression.

METHODS: Data were obtained from several national Swedish registers. All patients with bipolar depression treated with ECT in any hospital in Sweden between 2011 and 2016 for whom information about ECT response was available were included (n = 1251). Response was defined as a score on the Clinical Global Impression - Improvement scale of one or two. Univariate and multivariate logistic regression were conducted to investigate associations between socio-demographic and clinical factors and response.

RESULTS: Response was achieved in 80.2% patients. Older age was associated with higher response rate to ECT. Patients with comorbid obsessive-compulsive disorder or personality disorder, and patients previously treated with lamotrigine had lower response rate.

CONCLUSION: ECT for bipolar depression was associated with very high response rates. The strongest prognostic factors were higher age, absence of comorbid obsessive-compulsive disorder or personality disorder, and less prior pharmacologic treatment. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2019.
Keywords [en]
Bipolar disorders, bipolar depression, electroconvulsive therapy, prognosis
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-75577DOI: 10.1111/acps.13075PubMedID: 31334829OAI: oai:DiVA.org:oru-75577DiVA, id: diva2:1341661
Available from: 2019-08-09 Created: 2019-08-09 Last updated: 2019-08-09Bibliographically approved

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Popiolek, KatarzynaBejerot, SusanneBrus, OleNordenskjöld, Axel

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