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Metabolomics in the studies of islet autoimmunity and type 1 diabetes
VTT Technical Research Centre of Finland, Finland.ORCID iD: 0000-0002-2856-9165
2012 (English)In: The review of diabetic studies : RDS, ISSN 1614-0575, Vol. 9, no 4, p. 236-247Article in journal (Refereed) Published
Abstract [en]

The metabolome is sensitive to genetic and environmental factors contributing to complex diseases such as type 1 diabetes (T1D). Metabolomics is the study of biochemical and physiological processes involving metabolites. It is therefore one of the key platforms for the discovery and study of pathophysiological phenomena leading to T1D and the development of T1D-associated complications. Although the application of metabolomics in T1D research is still rare, metabolomic research has already advanced across the full spectrum, from disease progression to the development of diabetic complications. Metabolomic studies in T1D have contributed to an improved etiopathogenic understanding and demonstrated their potential in the clinic. For example, metabolomic data from recent T1D studies suggest that a specific metabolic profile, or metabotype, precedes islet autoimmunity and the development of overt T1D. These early metabolic changes are attributed to many biochemical pathways, thus suggesting a systemic change in metabolism which may be inborn. Based on this evidence, the role of the metabolome in the progression to T1D is therefore to facilitate specific biochemical processes associated with T1D, and to contribute to the development of a vulnerable state in which disease is more likely to be triggered. This may have important implications for the understanding of T1D pathophysiology and early disease detection and prevention.

Place, publisher, year, edition, pages
Society for Biomedical Diabetes Research (SBDR) , 2012. Vol. 9, no 4, p. 236-247
Keywords [en]
Allostasis, autoimmunity, biomarker, lipid metabolism, lipidomics, metabolomics, systems biology
National Category
Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:oru:diva-70987DOI: 10.1900/RDS.2012.9.236PubMedID: 23804263Scopus ID: 2-s2.0-84879520258OAI: oai:DiVA.org:oru-70987DiVA, id: diva2:1345694
Available from: 2019-08-26 Created: 2019-08-26 Last updated: 2019-08-28Bibliographically approved

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Oresic, Matej

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf