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Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome
Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland; Valio Ltd, Research Centre, Helsinki, Finland.
Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland; Valio Ltd, Research Centre, Helsinki, Finland.
Tampere Health Centre and Department of Medicine, Tampere City Hospital, Tampere, Finland.
Tampere Health Centre and Department of Medicine, Tampere City Hospital, Tampere, Finland.
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2009 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 15, no 48, p. 6068-6074Article in journal (Refereed) Published
Abstract [en]

AIM: To investigate the pathophysiology of irritable bowel syndrome (IBS) by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.

METHODS: Fifteen IBS patients fulfilling the Rome II criteria, and nine healthy volunteers were included in the study. A combined lipidomics (UPLC/MS) and metabolomics (GC x GC-TOF) approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.

RESULTS: Overall, lipid levels were elevated in patients with IBS. The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines. Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides, glycosphingolipids, and di- and triacylglycerols. Among the metabolites, the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects (P = 0.03).

CONCLUSION: IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile. Especially, there was an increase in several lipid species such as lysophospholipids and ceramides.

Place, publisher, year, edition, pages
Baishideng Publishing Group Co., Limited , 2009. Vol. 15, no 48, p. 6068-6074
Keywords [en]
Functional gastrointestinal diseases, Irritable bowel syndrome, Histopathology
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-70946DOI: 10.3748/wjg.15.6068ISI: 000273200200008PubMedID: 20027679Scopus ID: 2-s2.0-75349109603OAI: oai:DiVA.org:oru-70946DiVA, id: diva2:1345855
Available from: 2019-08-26 Created: 2019-08-26 Last updated: 2019-09-05Bibliographically approved

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