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Application of lipidomics and metabolomics to the study of adipose tissue
VTT Technical Research Centre of Finland, Espoo, Finland.
VTT Technical Research Centre of Finland, Espoo, Finland.
VTT Technical Research Centre of Finland, Espoo, Finland.
VTT Technical Research Centre of Finland, Espoo, Finland.ORCID iD: 0000-0002-2856-9165
2008 (English)In: Methods in Molecular Biology, ISSN 1064-3745, E-ISSN 1940-6029, Vol. 456, p. 123-130Article in journal (Refereed) Published
Abstract [en]

Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.

Place, publisher, year, edition, pages
Humana Press, 2008. Vol. 456, p. 123-130
Keywords [en]
Metabolomics, lipidomics, branched chain amino acids, liquid chro-matography, gas chromatography, mass spectrometry, insulin resistance
National Category
Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:oru:diva-70912DOI: 10.1007/978-1-59745-245-8_9PubMedID: 18516557Scopus ID: 2-s2.0-84934441481OAI: oai:DiVA.org:oru-70912DiVA, id: diva2:1345880
Available from: 2019-08-26 Created: 2019-08-26 Last updated: 2019-08-30Bibliographically approved

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Oresic, Matej

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  • Other locale
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