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Gut microbiota affects lens and retinal lipid composition
VTT Technical Research Centre of Finland, Espoo, Finland; Institute of Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.ORCID iD: 0000-0002-2856-9165
VTT Technical Research Centre of Finland, Finland.
VTT Technical Research Centre of Finland, Finland.
Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
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2009 (English)In: Experimental Eye Research, ISSN 0014-4835, E-ISSN 1096-0007, Vol. 89, no 5, p. 604-607Article in journal (Refereed) Published
Abstract [en]

The gut microbiota affects host lipid metabolism and is considered an environmental factor that contributes to development of obesity. To investigate whether the gut microbiota affects the eye lipidome, we performed comprehensive lipidomic profiling of lens and retina from conventionally raised and germ-free mice. Conventionally raised mice had diminished phosphatidylcholines in the lens and elevated ethanolamine plasmalogens in the retina. Diminishment of lens phosphatidylcholines in the presence of gut microbiota suggests that the conventionally raised mice are exposed over time to more oxidative stress than germ-free mice. Consistent with this, their lifespan is also shorter. Our findings may open a new area of investigation how modulation of gut microbiota affects the eye health.

Place, publisher, year, edition, pages
Academic Press, 2009. Vol. 89, no 5, p. 604-607
Keywords [en]
Lipidomics, lens, retina, gut microbiota, phosphatidylcholine, plasmalogen, allostasis, oxidative stress
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-70941DOI: 10.1016/j.exer.2009.06.018ISI: 000270850800002PubMedID: 19591827Scopus ID: 2-s2.0-70349440948OAI: oai:DiVA.org:oru-70941DiVA, id: diva2:1345881
Available from: 2019-08-26 Created: 2019-08-26 Last updated: 2019-08-28Bibliographically approved

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Oresic, Matej

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