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Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA, USA; Department of Physiology, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Department of Medicine, University of California, Los Angeles, CA, USA.
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA, USA.
VTT Technical Research Centre of Finland, Espoo, Finland.
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2008 (English)In: Journal of Lipid Research, ISSN 0022-2275, E-ISSN 1539-7262, Vol. 49, no 9, p. 2038-2044Article in journal (Refereed) Published
Abstract [en]

The liver secretes triglyceride-rich VLDLs, and the triglycerides in these particles are taken up by peripheral tissues, mainly heart, skeletal muscle, and adipose tissue. Blocking hepatic VLDL secretion interferes with the delivery of liver-derived triglycerides to peripheral tissues and results in an accumulation of triglycerides in the liver. However, it is unclear how interfering with hepatic triglyceride secretion affects adiposity, muscle triglyceride stores, and insulin sensitivity. To explore these issues, we examined mice that cannot secrete VLDL [due to the absence of microsomal triglyceride transfer protein (Mttp) in the liver]. These mice exhibit markedly reduced levels of apolipoprotein B-100 in the plasma, along with reduced levels of triglycerides in the plasma. Despite the low plasma triglyceride levels, triglyceride levels in skeletal muscle were unaffected. Adiposity and adipose tissue triglyceride synthesis rates were also normal, and body weight curves were unaffected. Even though the blockade of VLDL secretion caused hepatic steatosis accompanied by increased ceramides and diacylglycerols in the liver, the mice exhibited normal glucose tolerance and were sensitive to insulin at the whole-body level, as judged by hyperinsulinemic euglycemic clamp studies. Normal hepatic glucose production and insulin signaling were also maintained in the fatty liver induced by Mttp deletion. Thus, blocking VLDL secretion causes hepatic steatosis without insulin resistance, and there is little effect on muscle triglyceride stores or adiposity.

Place, publisher, year, edition, pages
American Society for Biochemistry and Molecular Biology, 2008. Vol. 49, no 9, p. 2038-2044
Keywords [en]
Microsomal triglyceride transfer protein, triglyceride-rich lipoprotein, fatty liver, insulin resistance, obesity, de novo lipogenesis, ceramide, diacylglycerol
National Category
Other Basic Medicine
Identifiers
URN: urn:nbn:se:oru:diva-70922DOI: 10.1194/jlr.M800248-JLR200ISI: 000258472500018PubMedID: 18515909Scopus ID: 2-s2.0-53149101726OAI: oai:DiVA.org:oru-70922DiVA, id: diva2:1345908
Available from: 2019-08-26 Created: 2019-08-26 Last updated: 2019-08-28Bibliographically approved

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