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Role of cardiolipins in the inner mitochondrial membrane: insight gained through atom-scale simulations
Department of Physics, Tampere University of Technology, Temrpere, Finland.
Department of Physical Chemistry, Barcelona University, Spain.
VTT Technical Research Centre of Finland, Espoo, Finland.
VTT Technical Research Centre of Finland, Espoo, Finland.ORCID iD: 0000-0002-2856-9165
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2009 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 113, no 11, p. 3413-3422Article in journal (Refereed) Published
Abstract [en]

Mitochondrial membranes are unique in many ways. Unlike other cellular membranes, they are comprised of two membranes instead of just one, and cardiolipins, one of the abundant lipid species in mitochondrial membranes, are not found in significant amounts elsewhere in the cell. Among other aspects, the exceptional nature of cardiolipins is characterized by their small charged head group connected to typically four hydrocarbon chains. In this work, we present atomic-scale molecular dynamics simulations of the inner mitochondrial membrane modeled as a mixture of cardiolipins (CLs), phosphatidylcholines (PCs), and phosphatidylethanolamines (PEs). For comparison, we also consider pure one-component bilayers and mixed PC-PE, PC-CL, and PE-CL membranes. We find that the influence of CLs on membrane properties depends strongly on membrane composition. This is highlighted by studies of the stability of CL-containing membranes, which indicate that the interactions of CL in ternary lipid bilayers cannot be deduced from the corresponding ones in binary membranes. Moreover, while the membrane properties in the hydrocarbon region are only weakly affected by CLs, the changes at the membrane-water interface turn out to be prominent. The effects at the interface are most evident in membrane properties related to hydrogen bonding and the binding phenomena associated with electrostatic interactions.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2009. Vol. 113, no 11, p. 3413-3422
National Category
Bioinformatics and Systems Biology
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URN: urn:nbn:se:oru:diva-70934DOI: 10.1021/jp8077369ISI: 000264111200021PubMedID: 19228006Scopus ID: 2-s2.0-65249133096OAI: oai:DiVA.org:oru-70934DiVA, id: diva2:1345917
Available from: 2019-08-26 Created: 2019-08-26 Last updated: 2019-08-28Bibliographically approved

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Oresic, Matej

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