This article uses the philosophy of critical realism to overcome the problem that most contemporary guidelines for interdisciplinary research fail to provide would-be researchers with adequate advice. It arrives at five important steps in the interdisciplinary research process: an initial planning phase; a disciplinary phase; a teamwork phase characterized by cross-disciplinary understanding; and a transdisciplinary, creative phase that involves epistemic emergence, and that results in the integration of knowledge. The fifth phase is the result of the integrative fourth phase; it provides a holistic interdisciplinary understanding of the involved structures and mechanisms of the issue at hand. To make interventions derived from interdisciplinary research useful, they must be disseminated in such way as to include a return to reality, that is, there must be a movement from epistemology to ontology.