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Impact Of Physical Activity On N-glycan Profile In Older Adults
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-9831-0896
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-3025-0719
University of Bologna, Bologna, Italy.
University of Bologna, Bologna, Italy.
2019 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 51, no 6, p. 542-542Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

The biological mechanisms underlying the beneficial effects of regular physical activity (PA) on prevention of chronic diseases are not fully understood. It is currently suggested that N-linked enzymatic glycosylation, a post-translational modification modulating the biological function of several proteins, may contribute to disease development. Nevertheless, the influence of PA on N-glycans in humans has never been explored.

PURPOSE: To explore serum N-glycan profile in a sample of community-dwelling older women with different objectively assessed PA levels and metabolic risk status.

METHODS: Components of the metabolic syndrome (MetS) and serum N-glycans analyzed using DSA-FACE technology were assessed in 109 older community-dwelling women (65-70 yrs). Ten peaks, each representing a unique N-glycan structure were detected. Adherence to PA guidelines was determined using accelerometry. Participants daily engaged in 30 minutes of MVPA were classified as meeting PA guidelines.

RESULTS: Significant differences in N-glycan peaks were indicated when comparing women adhering to the PA guideline to those less active: when adjusted by MetS, a 12% (p = 0.006) and a 13% (p = 0.004) lower level of NA3 (peak 8) and NA4 (peak 10), respectively, were evident among the physically active women compared to those less active. In contrast to findings based on the MVPA threshold, no differences in N-glycan peaks were observed between PA groups when based on the lower intensity threshold, which may indicate that the influence on N-glycan levels by PA is intensity-sensitive.

CONCLUSIONS: Adherence to PA guidelines is related to a favorable N-glycan profile, regardless of metabolic risk status. This proposed effect on N-glycans only occurs above the moderate PA-intensity threshold. Our findings support the promotion of a physically active lifestyle as a supporting non-pharmacological public health approach.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2019. Vol. 51, no 6, p. 542-542
National Category
Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:oru:diva-76069DOI: 10.1249/01.mss.0000562129.57753.adISI: 000481662802132OAI: oai:DiVA.org:oru-76069DiVA, id: diva2:1348673
Conference
Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Orlando, FL, USA, May 28 - June 1, 2019
Available from: 2019-09-05 Created: 2019-09-05 Last updated: 2019-09-05Bibliographically approved

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Kadi, FawziNilsson, Andreas

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