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Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum
Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Cell & Molecular Biology, Uppsala University, Uppsala, Sweden.
Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
NIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, USA.
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2019 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 9, no 1, article id 15385Article in journal (Refereed) Published
Abstract [en]

The search for biomarkers associated with obesity-related diseases is ongoing, but it is not clear whether plasma and serum can be used interchangeably in this process. Here we used high-throughput screening to analyze 358 proteins and 76 lipids, selected because of their relevance to obesity-associated diseases, in plasma and serum from age- and sex-matched lean and obese humans. Most of the proteins/lipids had similar concentrations in plasma and serum, but a subset showed significant differences. Notably, a key marker of cardiovascular disease PAI-1 showed a difference in concentration between the obese and lean groups only in plasma. Furthermore, some biomarkers showed poor correlations between plasma and serum, including PCSK9, an important regulator of cholesterol homeostasis. Collectively, our results show that the choice of biofluid may impact study outcome when screening for obesity-related biomarkers and we identify several markers where this will be the case.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, no 1, article id 15385
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:oru:diva-77688DOI: 10.1038/s41598-019-51673-0ISI: 000492832000003PubMedID: 31659186Scopus ID: 2-s2.0-85074193570OAI: oai:DiVA.org:oru-77688DiVA, id: diva2:1366787
Funder
Knut and Alice Wallenberg FoundationSwedish Research Council, 2016/82Swedish Society for Medical Research (SSMF), S150086Åke Wiberg Foundation, M15-0058EU, European Research Council, 804418Swedish Heart Lung Foundation, HL128457 HL107744 20180199
Note

Funding Agencies:

Wallenberg Centre for Molecular & Translational Medicine at University of Gothenburg

United States Department of Health & Human Services National Institutes of Health (NIH) - USA U24 DK097154

United States Department of Health & Human Services National Institutes of Health (NIH) - USA U24 DK097154U2C 030158

United States Department of Agriculture (USDA) 2032-51530-022-00D

United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Heart Lung & Blood Institute (NHLBI)

Available from: 2019-10-30 Created: 2019-10-30 Last updated: 2022-09-15Bibliographically approved

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