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Vaccinations and chronic illness in Swedish children preceding diagnosis of leukemia, malignant lymphoma or brain tumor
Örebro University, Department of Clinical Medicine.
(English)Manuscript (preprint) (Other academic)
National Category
Medical and Health Sciences Cancer and Oncology
Research subject
Medicine; Oncology
Identifiers
URN: urn:nbn:se:oru:diva-3101OAI: oai:DiVA.org:oru-3101DiVA, id: diva2:136978
Available from: 2006-09-01 Created: 2006-09-01 Last updated: 2017-10-18Bibliographically approved
In thesis
1. Epidemiological aspects on malignant diseases in childhood
Open this publication in new window or tab >>Epidemiological aspects on malignant diseases in childhood
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The trends of malignant diseases in children aged 0 to 14 years, reported to the Swedish Cancer Registry 1960–1998 (n=9 298) were analyzed. The most common diagnoses were leukemia, 29.7%, tumors of the central nervous system (CNS), 27.6%, and lymphomas, 10.2%. The average annual incidence rate of childhood malignant diseases 1990–1998 was 16.19/100 000 person-years. Average annual change in incidence rate of all childhood cancer was +1.01% (95% confidence interval (CI)=0.80-1.22). Statistically significant increase was seen for leukemia +0.85% (95% CI=0.42–1.28), lymphomas +1.87% (95% CI=1.17–2.58), CNS tumors +1.45% (95% CI=1.02–1.88), sympathetic nervous system tumors +1.61% (95% CI=0.79–2.44), hepatic tumors +2.62% (95% CI=2.02–3.21), and germ cell and gonadal tumors +1.21% (95% CI=0.23–2.19).

Children are exposed to persistent organic pollutants (POPs) during fetal life and breast-feeding. In a case-control study including cases of childhood cancer reported to the Cancer Registry 1988–1991 (n=962) we used breastfeeding duration as a surrogate for exposure to POPs. One matched control per case was used. Information on breast-feeding, vaccinations and chronic illness was collected from copies of the children’s Child Health Center records.

Overall, breast-feeding did not affect the risk of childhood cancer, OR=1.0 (95% CI=0.7–1.3) using breast-feeding up to one month as reference. For non-Hodgkin lymphoma (NHL) OR for breast-feeding for >1 month yielded OR=5.0 (95% CI=1.1–23).

No association was seen between preschool vaccinations and childhood cancer except for lymphomas and measles/measles-mumps-rubella vaccination, OR=0.2 (95% CI=0.1–0.6). Increased risk of all cancer was found for congenital malformations, OR=1.7 (95% CI=0.97–2.9), especially of leukemia, OR=3.0 (95% CI=1.5–5.8). Children with disorders of brain function had an increased risk of all cancer, OR=6.0 (95% CI=1.3–27), especially of brain tumors, OR=10 (95% CI=1.3–78).

A childhood population expected to be more exposed to POPs is children of fishermen. In a register-based study, the cancer incidence rates in a cohort of fishermen children (at age 0-19 years) were compared to the rates of referent children. A modestly increased incidence rate ratio (IRR) of childhood cancer was found, IRR=1.38 (95% CI=0.96–2.00) and an increased IRR for acute lymphoid leukemia, IRR=2.65 (95% CI=1.005–6.97). In west coast fishermen children, an increased IRR was observed for NHL, IRR=3.19 (95% CI=0.98–10.4).

Place, publisher, year, edition, pages
Örebro: Örebro universitetsbibliotek, 2006. p. 91
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 7
Keyword
childhood cancer, incidence rates, persistent organic pollutants, breast-feeding
National Category
Medical and Health Sciences Cancer and Oncology
Research subject
Medicine; Oncology
Identifiers
urn:nbn:se:oru:diva-585 (URN)91-7668-494-6 (ISBN)
Public defence
2006-09-22, Wilandersalen, Universitetssjukhuset, Örebro, 13:15
Opponent
Supervisors
Available from: 2006-09-01 Created: 2006-08-28 Last updated: 2017-10-18Bibliographically approved

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Dreifaldt, Ann Charlotte

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CiteExportLink to record
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