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Laser treatment of localized squamous cell carcinoma of the penis
Örebro University, Department of Clinical Medicine.
1995 (English)In: Journal of Urology, ISSN 0022-5347, E-ISSN 1527-3792, Vol. 154, no 3, p. 1020-1023Article in journal (Refereed) Published
Abstract [en]

PURPOSE:

We evaluate the efficacy and morbidity of laser and conventional treatment in 32 men with penile cancer.

MATERIALS AND METHODS:

Of 32 men treated for squamous cell carcinoma of the penis observed for an average of 44 months 19 were treated with the combined carbon dioxide and neodymium: YAG lasers. The 13 patients treated conventionally had more advanced disease and they were a mean 17 years older than those in the laser treated group.

RESULTS:

All laser treated patients were disease-free after a mean of 31 months. Among the 13 conventionally treated patients there were only 5 long-term survivors.

CONCLUSIONS:

The cosmetic and functional outcome of laser treatment for stages Tis to T2N0M0, grades 1 and 2 squamous cell carcinoma of the penis is excellent, and the associated morbidity rate is low.

Place, publisher, year, edition, pages
1995. Vol. 154, no 3, p. 1020-1023
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-3149PubMedID: 7637046OAI: oai:DiVA.org:oru-3149DiVA, id: diva2:137163
Available from: 2004-05-19 Created: 2004-05-19 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Clinical aspect of laser treatment of lichen sclerosus and squamous cell carcinoma of the penis
Open this publication in new window or tab >>Clinical aspect of laser treatment of lichen sclerosus and squamous cell carcinoma of the penis
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim of these studies was to investigate the efficacy, complications and the long term results after laser treatment of lichen sclerosus et atrophicus and of squamous cell carcinoma of the penis.

Patients and Methods: Paper I: In a prospective study from 1985-1991, 62 men with histologically verified lichen sclerosus et atrophicus were given carbon dioxide (CO2) laser treatment following the failure of local corticosteroid treatment. The study was subsequently updated at a median follow-up time of 14 years.

Paper II-IV: Sixty-seven men aged 26 to 87 (mean 60 years) with newly diagnosed penile carcinoma were included in a prospective study. The patients were treated by a new combined laser method (CO2 and Nd:YAG) between 1986 and 2000. The median follow-up time was 42 months (range 12-186 months). All patients could be assessed for local recurrence, progression and survival at the end of 2001. Forty-six patients agreed to participate in face-to-face interviews addressing sexual activity, sexual function/dysfunction, satisfaction and cosmetic results.

Results: Paper I: The laser treatment was successful in 47 patients (76%) with no local symptoms at a mean follow-up of 30 months. Fifty-three of the 62 men were alive when the update was carried out in February 2004, and we were able to get in contact with 50 of them. Forty of these patients (80%) had no local symptoms or visible lesion. We found concomitant squamous cell carcinoma of the penis in two patients and two further patients had died from anal cancer.

Paper II-IV: Local recurrences appeared in 13 patients (19%) at a median follow up of 42 months, and 10 of these patients were successfully retreated with laser treatment. Two patients died from penile carcinoma. The disease-specific 5-years survival rate was 95%. Concomitant lichen sclerosus was found in 11 patients. All patients younger than 75 years reported that they were sexually active before the treatment, and 80% of them had resumed their sexual activity after the treatment. Ten patients (22%) reported decreased erectile function after the treatment, while 33 patients (72%) reported unaltered erectile function. The cosmetic result was regarded as satisfying or very satisfying in 78% of the patients.

Conclusion: Carbon dioxide laser treatment is an efficient treatment for lichen sclerosus et atrophicus with excellent long-term results, and the side effects are few. One disadvantages of the treatment is a slow postoperative healing process. Combined CO2 and Nd:YAG laser treatment is effective for treatment of the primary tumour in patients with localized penile carcinoma. It can be safely carried out with good local tumour control and highly satisfactory results with respect to cosmetic aspects and sexual function.

Place, publisher, year, edition, pages
Örebro: Örebro universitetsbibliotek, 2004. p. 51
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 3
Keywords
Medicin, Penile diseases, lichens, penile neoplasms, lasers, carcinoma, squamous cell carcinoma, sexual function, sexaul satisfaction, medicin
National Category
Dermatology and Venereal Diseases
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-72 (URN)91-7668-393-1 (ISBN)
Public defence
2004-06-10, Wilandersalen, Universitetssjukhuset, Örebro, 13:00 (English)
Opponent
Supervisors
Available from: 2004-05-19 Created: 2004-05-19 Last updated: 2017-10-18Bibliographically approved

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