oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
HIV-1 resistensgivande genetiska variationer rörande CD4+ T-lymfocyteroch induktion av resistens: En systematisk litteraturstudieom rådande kunskaper och potentiella lösningartill en global kris
Örebro University, School of Medical Sciences.
2019 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Background.HIV-1 is one of mankind’s largestpandemics and is associated with great social stigma. There are effective antiretroviral medications capable of halting disease progress but no definitive cure. However, a few individuals have been shown to be resistant to HIV-1. Recent advances in genetic engineering, namely CRISPR/Cas9,presentopportunities to artificially induce HIV-1 resistance inhumans.

Aim.This systematic literature review aimedto identify genetic variations affecting CD4+ T-lymphocytes associatedwith resistance towards HIV-1 establishment,to highlightpotentialcandidatestogenetically engineer HIV-1 resistanthumans.

Material and methods.The searchwas done in PubMed with no timerestriction andresulted in 1109 articles. Application of inclusioncriteria (“Human”)narrowed the results down to 956 articles.Exclusion criteria (“Review”) was subsequently applied.The remaining articlesunderwent a relevance analysiswhere therelevance criteria went from less specific in the title analysis to more specific in the full text analysis. After title, abstract, full text and quality analysis, 11 articleswereincluded in this study.

Results.In vitro experiments and genetic population studiesshowed thatpolymorphisms CCR5-Δ32, HAVCR1 S/S and ZNRD1 Hap2 were significantly associated withhigher prevalence of variation bearing individuals in high exposure HIV-1 seronegative groups compared to non-bearingindividuals andCCR5-Δ32showedresistance to HIV-1 in cell inoculationsstudies.

Conclusions.CCR5-Δ32, HAVCR1 S/S and ZNRD1 Hap2 wereshown to correlate with HIV-1 resistance and are potential candidates to be inducedwith CRISPR/Cas9 with the aim of achieving HIV-1 resistantindividuals.However, their eventual drawbacks needto be identified

Place, publisher, year, edition, pages
2019.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:oru:diva-78025OAI: oai:DiVA.org:oru-78025DiVA, id: diva2:1372420
Subject / course
Medicine
Supervisors
Examiners
Available from: 2019-11-23 Created: 2019-11-23 Last updated: 2019-11-23Bibliographically approved

Open Access in DiVA

fulltext(1930 kB)3 downloads
File information
File name FULLTEXT02.pdfFile size 1930 kBChecksum SHA-512
d7757e81480d0b424a43acac6e661eb5ffdbdce22521a23499d54593b8e24d62ba82c4fc8ed925c60ec8b8eecfdc6d18cd4b6ae6a81aca905c864603031104d4
Type fulltextMimetype application/pdf

By organisation
School of Medical Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 3 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 2 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf