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Physical performance and muscular characteristics in different stages of COPD
Örebro University, School of Health and Medical Sciences.
Örebro University, School of Health and Medical Sciences.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (RISPA- MEP-RG)ORCID iD: 0000-0002-9831-0896
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2009 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 19, no 6, p. 865-870Article in journal (Refereed) Published
Abstract [en]

This study has examined exercise capacity and muscle morphology in patients with different severities of chronic obstructive pulmonary disease (COPD). Twenty-three patients and 12 healthy matched controls were recruited. Based on the severity of airflow obstruction, patients were divided into two subgroups. Exercise capacity was determined using a 6-min walk test. Muscle fiber composition, fiber area and number of satellite cells/muscle fiber were determined in muscle biopsies using immunohistochemistry. A progressive decline in exercise capacity was noted with ascending disease severity. Furthermore, a correlation between reduction in exercise capacity and changes in muscle fiber composition was observed in COPD. The group with severe and very severe COPD had a lower proportion of type I and a higher proportion of type IIa fibers compared with the other groups. In severe and very severe COPD, a reduction in fiber area of type IIa fibers was also seen. The number of satellite cells/muscle fiber did not differ between the groups. In conclusion, a decline in exercise capacity occurs already in mild and moderate COPD, indicating that the 6-min walk test is a reliable indicator of disease severity. Furthermore, changes in skeletal muscle morphology are associated with disease severity while muscle regenerative capacity is not altered.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2009. Vol. 19, no 6, p. 865-870
Keyword [en]
Activities of Daily Living/*psychology, Adaptation; Psychological, Aged, Aged; 80 and over, Attitude to Health, Body Image, Dependency (Psychology), Female, Health Services Needs and Demand, Humans, Interpersonal Relations, Male, Middle Aged, Models; Psychological, Neoplasms/psychology, Nursing Methodology Research, Palliative Care/methods/*psychology, Power (Psychology), Quality of Life/psychology, Questionnaires, Respite Care/psychology, Self Concept, Social Support, Sweden
National Category
Medical and Health Sciences Physiology Respiratory Medicine and Allergy Sport and Fitness Sciences
Research subject
Physiology; Sports Science
Identifiers
URN: urn:nbn:se:oru:diva-3417DOI: 10.1111/j.1600-0838.2008.00858.xISI: 000272132200014PubMedID: 18980606Scopus ID: 2-s2.0-70450260481OAI: oai:DiVA.org:oru-3417DiVA, id: diva2:137714
Available from: 2008-12-04 Created: 2008-12-04 Last updated: 2018-01-13Bibliographically approved
In thesis
1. Sceletal muscle characteristics and physical activity patterns in COPD
Open this publication in new window or tab >>Sceletal muscle characteristics and physical activity patterns in COPD
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. Besides abnormities within the respiratory system COPD is also associated with effects outside the lungs, so called systemic effects. One systemic effect that has been highlighted is skeletal muscle dysfunction which has also been associated with reduced exercise capacity. Apart from changes in muscle morphology, low levels of physical activity have also been suggested as a plausible mediator of reduced exercise capacity in COPD. The aim of this thesis was to study muscle morphology and physical activity patterns in patients with different degrees of COPD and to examine the associations between muscle morphology, physical activity and exercise capacity in these patients. Skeletal muscle morphology was found to shift towards a more glycolytic muscle profile in COPD patients and changes in muscle morphology were found to be correlated to disease severity and to exercise capacity. Muscle capillarization was also found to be lower in COPD compared with healthy subjects and to be correlated to disease severity and exercise capacity. When studying signalling pathways involved in muscle capillarization, an overexpression of VHL was found in patients with mild and moderate COPD compared with healthy subjects. Furthermore, COPD patients were found to be less physically active compared with healthy subjects and the level of physical activity was associated with exercise capacity.In conclusion, changes in skeletal muscle morphology and low levels of physical activity are present in COPD patients and may partly explain the lower exercise capacity observed in these patients. The more glycolytic muscle profile in COPD is suggested to be mediated by hypoxia and low levels of physical activity in this patient group. Furthermore, increased levels of VHL may lead to impaired transduction of the hypoxic signalling pathway, which may contribute to the decreased muscle capillarization observed in COPD.

Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2010. p. 65
Series
Örebro Studies in Sport Sciences, ISSN 1654-7535 ; 10
Keyword
COPD, muscle morphology, muscle fibre distribution, muscle capillarization, physical activity, von Hippel-Lindau protein, exercise capacity
National Category
Social Sciences Interdisciplinary Sport and Fitness Sciences
Research subject
Sports Science
Identifiers
urn:nbn:se:oru:diva-12341 (URN)978-91-7668-768-0 (ISBN)
Public defence
2011-01-14, Hörsal P2, Fakutetsgatan 1, Örebro universitet, Örebro, 13:00
Opponent
Supervisors
Available from: 2010-10-27 Created: 2010-10-27 Last updated: 2018-01-12Bibliographically approved

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Eliason, GabriellaAbdel-Halim, S.Kadi, FawziPiehl-Aulin, Karin

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Eliason, GabriellaAbdel-Halim, S.Kadi, FawziPiehl-Aulin, Karin
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