Physical performance and muscular characteristics in different stages of COPDShow others and affiliations
2009 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 19, no 6, p. 865-870Article in journal (Refereed) Published
Abstract [en]
This study has examined exercise capacity and muscle morphology in patients with different severities of chronic obstructive pulmonary disease (COPD). Twenty-three patients and 12 healthy matched controls were recruited. Based on the severity of airflow obstruction, patients were divided into two subgroups. Exercise capacity was determined using a 6-min walk test. Muscle fiber composition, fiber area and number of satellite cells/muscle fiber were determined in muscle biopsies using immunohistochemistry. A progressive decline in exercise capacity was noted with ascending disease severity. Furthermore, a correlation between reduction in exercise capacity and changes in muscle fiber composition was observed in COPD. The group with severe and very severe COPD had a lower proportion of type I and a higher proportion of type IIa fibers compared with the other groups. In severe and very severe COPD, a reduction in fiber area of type IIa fibers was also seen. The number of satellite cells/muscle fiber did not differ between the groups. In conclusion, a decline in exercise capacity occurs already in mild and moderate COPD, indicating that the 6-min walk test is a reliable indicator of disease severity. Furthermore, changes in skeletal muscle morphology are associated with disease severity while muscle regenerative capacity is not altered.
Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2009. Vol. 19, no 6, p. 865-870
Keyword [en]
Activities of Daily Living/*psychology, Adaptation; Psychological, Aged, Aged; 80 and over, Attitude to Health, Body Image, Dependency (Psychology), Female, Health Services Needs and Demand, Humans, Interpersonal Relations, Male, Middle Aged, Models; Psychological, Neoplasms/psychology, Nursing Methodology Research, Palliative Care/methods/*psychology, Power (Psychology), Quality of Life/psychology, Questionnaires, Respite Care/psychology, Self Concept, Social Support, Sweden
National Category
Medical and Health Sciences Physiology Respiratory Medicine and Allergy Sport and Fitness Sciences
Research subject
Physiology; Sports Science
Identifiers
URN: urn:nbn:se:oru:diva-3417DOI: 10.1111/j.1600-0838.2008.00858.xISI: 000272132200014PubMedID: 18980606Scopus ID: 2-s2.0-70450260481OAI: oai:DiVA.org:oru-3417DiVA, id: diva2:137714
2008-12-042008-12-042018-01-13Bibliographically approved
In thesis