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Increased sporulation rate of epidemic Clostridium difficile Type 027/NAP1
Örebro University, School of Health and Medical Sciences.
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2008 (English)In: Journal of Clinical Microbiology, ISSN 0095-1137, E-ISSN 1098-660X, Vol. 46, no 4, p. 1530-1533Article in journal (Refereed) Published
Abstract [en]

Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the same tcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type 027 isolates, a feature that should contribute to its survival and spread. 

Place, publisher, year, edition, pages
2008. Vol. 46, no 4, p. 1530-1533
Keywords [en]
Aged; 80 and over, Anti-Bacterial Agents/pharmacology, Aza Compounds/pharmacology, Bacterial Proteins/genetics/metabolism, Clostridium difficile/*classification/drug effects/genetics/*physiology, Disease Outbreaks, Enterocolitis; Pseudomembranous/*epidemiology/microbiology, Humans, Microbial Sensitivity Tests, Middle Aged, Quinolines/pharmacology, Repressor Proteins/genetics/metabolism, Ribotyping, Spores; Bacterial/physiology, Virulence
National Category
Medical and Health Sciences Microbiology in the medical area
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-3471DOI: 10.1128/JCM.01964-07PubMedID: 18287318OAI: oai:DiVA.org:oru-3471DiVA, id: diva2:137768
Available from: 2008-12-08 Created: 2008-12-08 Last updated: 2018-01-13Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18287318&dopt=Citation

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Unemo, MagnusNorén, Torbjörn

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CiteExportLink to record
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Language
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Output format
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