oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Coeliac disease and risk of sepsis
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0003-1024-5602
Show others and affiliations
2008 (English)In: Gut, ISSN 0017-5749, E-ISSN 1468-3288, Vol. 57, no 8, p. 1074-1080Article in journal (Refereed) Published
Abstract [en]

Objective: To examine the risk of subsequent sepsis in individuals with coeliac disease.Design: We used Swedish national health registers to identify 15 325 individuals with a diagnosis of coeliac disease (1964–2003) and 14 494 inpatient reference individuals. Cox regression estimated the hazard ratios (HRs) for subsequent sepsis.Results: Compared with inpatient reference individuals, individuals with coeliac disease were at increased risk of sepsis (HR  = 1.6, 95% confidence interval (95% CI)  = 1.2 to 1.9, p<0.001). The highest risk estimates were seen for pneumococcal sepsis (HR  = 2.5, 95% CI  = 1.2 to 5.1, p = 0.014). Individuals with coeliac disease diagnosed in childhood were not at increased risk of subsequent sepsis (HR  = 1.0, 95% CI  = 0.6 to 1.9, p = 0.908). When individuals with coeliac disease were compared with reference individuals from the general population, coeliac disease was associated with an increased risk of sepsis (HR  = 2.6, 95% CI  = 2.1 to 3.0, p<0.001). The HR for pneumococcal sepsis was 3.9 (95% CI  = 2.2 to 7.0, p<0.001). In this comparison, children with coeliac disease were also at an increased risk of sepsis (HR  = 1.8, 95% CI  = 1.2 to 2.7, p = 0.003).Conclusion: This study showed a modestly increased risk of sepsis in patients with coeliac disease with the highest risk for pneumococcal sepsis. This risk increase was limited to those with coeliac disease diagnosed in adulthood. Potential explanations include hyposplenism, increased mucosal permeability and an altered composition of the intestinal glycocalyx in individuals with coeliac disease.

Place, publisher, year, edition, pages
London: BMJ Publishing , 2008. Vol. 57, no 8, p. 1074-1080
Keywords [en]
Adolescent, Adult, Age Factors, Aged, Aged; 80 and over, Celiac Disease/*complications/epidemiology, Child, Child; Preschool, Epidemiologic Methods, Female, Hospitalization/statistics & numerical data, Humans, Infant, Infant; Newborn, Male, Middle Aged, Opportunistic Infections/*complications/epidemiology, Pneumococcal Infections/complications/epidemiology, Sepsis/*complications/epidemiology, Sweden/epidemiology
National Category
Medical and Health Sciences Clinical Medicine
Research subject
Internal Medicine
Identifiers
URN: urn:nbn:se:oru:diva-3484DOI: 10.1136/gut.2007.133868PubMedID: 18270242OAI: oai:DiVA.org:oru-3484DiVA, id: diva2:137781
Available from: 2008-12-08 Created: 2008-12-08 Last updated: 2017-12-14Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18270242&dopt=Citation

Authority records BETA

Ludvigsson, Jonas F.Montgomery, Scott M.

Search in DiVA

By author/editor
Ludvigsson, Jonas F.Montgomery, Scott M.
By organisation
School of Health and Medical Sciences
In the same journal
Gut
Medical and Health SciencesClinical Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 461 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf