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A population-based study of coeliac disease, neurodegenerative and neuroinflammatory diseases
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0003-1024-5602
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-6328-5494
2007 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 25, no 11, p. 1317-1327Article in journal (Refereed) Published
Abstract [en]

Background

It has been suggested that coeliac disease (CD) is associated with several neurological diseases. However, the evidence of such an association is inconclusive as earlier research has often been based on small numbers with retrospective data collection.

Aim

To use Cox regression to examine the risk of neurological disease in individuals with CD.

Methods

Through Swedish national registers we identified some 14 000 individuals with a diagnosis of CD (1964–2003) and 70 000 reference individuals matched for age, sex, calendar year and county.

Results

Coeliac disease was associated with later polyneuropathy [hazard ratio (HR) = 3.4; 95% CI = 2.3–5.1]. We found no statistically significant association between CD and subsequent multiple sclerosis (HR = 0.9; 95% CI = 0.3–2.3), Parkinson’s disease (HR = 1.2; 95% CI = 0.8–1.9), Alzheimer’s disease (HR = 1.5; 95% CI = 0.9–2.6), hereditary ataxia (HR = 1.3; 95% CI = 0.5–3.6), the symptom ataxia (HR = 1.9; 95% CI = 0.6–6.2), Huntington’s disease (HR = 1.7; 95% CI = 0.3–8.6), myasthenia gravis (HR = 0.8; 95% CI = 0.2–3.8) or spinal muscular atrophy (HR = 0.5; 95% CI = 0.1–3.8). Prior polyneuropathy was associated with subsequent CD (odds ratio = 5.4; 95% CI = 3.6–8.2).

Conclusions

The association between CD and polyneuropathy indicates shared risks. We suggest that individuals with polyneuropathy routinely undergo screening for CD. There is no notable association between CD and other neurological outcomes investigated in this study.

Place, publisher, year, edition, pages
2007. Vol. 25, no 11, p. 1317-1327
Keywords [en]
Adult, Aged, Aged; 80 and over, Case-Control Studies, Celiac Disease/*complications/epidemiology, Female, Health Surveys, Humans, Male, Middle Aged, Neuritis/epidemiology/*etiology, Neurodegenerative Diseases/epidemiology/*etiology, Regression Analysis, Risk Factors, Socioeconomic Factors, Sweden/epidemiology
National Category
Medical and Health Sciences Gastroenterology and Hepatology Pharmaceutical Sciences Pharmaceutical Sciences Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Pharmaceutical Pharmacology; Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-3491DOI: 10.1111/j.1365-2036.2007.03329.xPubMedID: 17509100OAI: oai:DiVA.org:oru-3491DiVA, id: diva2:137788
Available from: 2008-12-08 Created: 2008-12-08 Last updated: 2018-01-13Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17509100&dopt=Citation

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Ludvigsson, Jonas F.Montgomery, Scott M.

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Citation style
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