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Vascular disease in a population-based cohort of individuals hospitalised with coeliac disease
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0003-1024-5602
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-6328-5494
2007 (English)In: Heart, ISSN 1355-6037, E-ISSN 1468-201X, Vol. 93, no 9, p. 1111-1115Article in journal (Refereed) Published
Abstract [en]

Objectives: To evaluate the risk of cardiovascular disease in individuals with coeliac disease (CD).

Design: Swedish national hospital-based register data were used to identify 13 358 individuals who had been diagnosed with CD (1964–2003) and 64 118 age-matched and sex-matched individuals without CD. Cox regression was used to estimate the risk of vascular disease in subjects with CD. Analyses were restricted to individuals with a follow-up of >1 year and with no vascular disease before study entry.

Results: CD was associated with myocardial infarction (HR 1.27; 95% CI 1.09 to 1.48), angina pectoris (1.46; 1.25 to 1.70), heart failure (1.41; 1.22 to 1.62), brain haemorrhage (1.40; 1.05 to 1.88) and ischaemic stroke (1.35; 1.14 to 1.60). These risk estimates were similar when analyses were restricted to adults in whom vascular disease had been listed as the main diagnosis. In post-hoc analyses, where reference individuals were restricted to inpatients, no association was found between CD and later vascular disease, except for a lower risk of heart failure (0.79; 0.68 to 0.92).

Conclusions: The positive association between CD and later vascular disease may be explained by ascertainment bias.

Place, publisher, year, edition, pages
2007. Vol. 93, no 9, p. 1111-1115
Keywords [en]
Adolescent, Adult, Aged, Aged; 80 and over, Angina Pectoris/epidemiology/etiology, Cardiovascular Diseases/epidemiology/*etiology, Celiac Disease/*complications/epidemiology, Child, Child; Preschool, Female, Heart Failure/epidemiology/etiology, Humans, Infant, Infant; Newborn, Intracranial Hemorrhages/epidemiology/etiology, Male, Middle Aged, Myocardial Infarction/epidemiology/etiology, Registries, Socioeconomic Factors, Stroke/epidemiology/etiology, Sweden/epidemiology
National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-3495DOI: 10.1136/hrt.2006.097097PubMedID: 17277354OAI: oai:DiVA.org:oru-3495DiVA, id: diva2:137792
Available from: 2008-12-08 Created: 2008-12-08 Last updated: 2017-12-14Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17277354&dopt=Citation

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Ludvigsson, Jonas F.Montgomery, Scott M.

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