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Coeliac disease and the risk of fractures: a general population-based cohort study
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0003-1024-5602
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-6328-5494
2007 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 25, no 3, p. 273-285Article in journal (Other academic) Published
Abstract [en]

Background: Earlier studies have suggested that untreated coeliac disease may be associated with osteoporosis, but results are contradictory for the risk of long-term fractures.Aim: To study the association between coeliac disease and fractures.Methods: We used Cox regresson to examine the future risk of hip fracture and fracture of any type in more than 13 000 individuals with coeliac disease and 65 000 age- and sex-matched reference individuals in a general population-based cohort.Results: During follow-up, 1365 first hip fractures and 4847 fractures of any type occurred. Coeliac disease was positively associated with subsequent hip fracture (hazard ratio = 2.1; 95% CI = 1.8-2.4) (in children: hazard ratio = 2.6; 95% CI = 1.1-6.2) and fractures of any type (hazard ratio = 1.4; 95% CI = 1.3-1.5) (in children: hazard ratio = 1.1; 95% CI = 1.0-1.2). The absolute excess risk of hip fractures in children with coeliac disease was 4/100 000 person-years. Incidence ratios for hip fracture in individuals with CD were around two both prior to diagnosis of coeliac disease and afterwards; this risk increase remained 20 years after diagnosis of coeliac disease.Conclusions: Individuals with coeliac disease, including children with coeliac disease, may be at increased risk of hip fracture and fracture of any type. Coeliac disease may be positively associated with long-term hip fracture risk.

Place, publisher, year, edition, pages
Oxford: Blackwell Scientific , 2007. Vol. 25, no 3, p. 273-285
Keywords [en]
Adolescent, Adult, Aged, Aged; 80 and over, Celiac Disease/*complications, Child, Child; Preschool, Cohort Studies, Female, Fractures; Bone/*etiology, Humans, Infant, Infant; Newborn, Male, Middle Aged, Risk Factors, Sweden/epidemiology
National Category
Pharmaceutical Sciences Pharmaceutical Sciences Medical and Health Sciences Gastroenterology and Hepatology Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Pharmaceutical Pharmacology
Identifiers
URN: urn:nbn:se:oru:diva-3496PubMedID: 17269989OAI: oai:DiVA.org:oru-3496DiVA, id: diva2:137793
Available from: 2008-12-08 Created: 2008-12-08 Last updated: 2018-01-13Bibliographically approved

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Ludvigsson, Jonas F.Montgomery, Scott M.

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