oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Celiac disease and risk of subsequent type 1 diabetes: a general population cohort study of children and adolescents
Örebro University, Department of Clinical Medicine.ORCID iD: 0000-0003-1024-5602
Örebro University, Department of Clinical Medicine.ORCID iD: 0000-0001-6328-5494
2006 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 29, no 11, p. 2483-2488Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE:

Earlier studies suggest that children with type 1 diabetes are more likely to have a subsequent diagnosis of celiac disease. However, research is sparse on the risk of subsequent type 1 diabetes in individuals with celiac disease. We sought to determine the risk of subsequent type 1 diabetes diagnosed before the age of 20 years in children and adolescents with celiac disease in a national, general population-based cohort.

RESEARCH DESIGN AND METHODS:

We identified 9,243 children with a diagnosis of celiac disease in the Swedish national inpatient register between 1964 and 2003. We then identified five reference individuals matched at time of diagnosis for age, calendar year, sex, and county (n = 45,680). Only individuals with >1 year of follow-up after study entry (diagnosis of celiac disease) were included in the analyses.

RESULTS:

Celiac disease was associated with a statistically significantly increased risk of subsequent type 1 diabetes before age 20 years (hazard ratio 2.4 [95% CI 1.9-3.0], P < 0.001). This risk increase was seen regardless of whether celiac disease was first diagnosed between 0 and 2 (2.2 [1.7-2.9], P < 0.001) or 3 and 20 (3.4 [1.9-6.1], P < 0.001) years of age. Individuals with prior celiac disease were also at increased risk of ketoacidosis or diabetic coma before the age of 20 years (2.3 [1.4-3.9], P = 0.001).

CONCLUSIONS:

Children with celiac disease are at increased risk of subsequent type 1 diabetes. This risk increase is low considering that 95% of individuals with celiac disease are HLA-DQ2 positive.

Place, publisher, year, edition, pages
2006. Vol. 29, no 11, p. 2483-2488
Keyword [en]
Adolescent, Adult, Age Distribution, Celiac Disease/*epidemiology, Child, Child; Preschool, Cohort Studies, Diabetes Mellitus; Type 1/*epidemiology, Diabetic Coma/epidemiology, Diabetic Ketoacidosis/epidemiology, Female, Humans, Infant, Infant; Newborn, Male, Registries, Risk Factors, Sex Distribution, Sweden/epidemiology
National Category
Medical and Health Sciences Biomedical Laboratory Science/Technology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-3499DOI: 10.2337/dc06-0794PubMedID: 17065689OAI: oai:DiVA.org:oru-3499DiVA, id: diva2:137796
Available from: 2008-12-08 Created: 2008-12-08 Last updated: 2017-12-14Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17065689&dopt=Citation

Authority records BETA

Ludvigsson, Jonas F.Montgomery, Scott M.

Search in DiVA

By author/editor
Ludvigsson, Jonas F.Montgomery, Scott M.
By organisation
Department of Clinical Medicine
In the same journal
Diabetes Care
Medical and Health SciencesBiomedical Laboratory Science/Technology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 320 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf