oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Coeliac disease and risk of renal disease: a general population cohort study
Örebro University, Department of Clinical Medicine.ORCID iD: 0000-0003-1024-5602
Örebro University, Department of Clinical Medicine.ORCID iD: 0000-0001-6328-5494
Show others and affiliations
2006 (English)In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 21, no 7, p. 1809-1815Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Coeliac disease (CD) may be a risk factor for renal disease.

METHODS:

We investigated the risk of any form of glomerulonephritis (GN) (acute, chronic and non-specified), chronic glomerulonephritis (CGN) and renal replacement therapy including dialysis treatment and kidney transplantation (KT) in patients with CD in a general population-based cohort study. We used Cox regression to assess the risk of renal disease in 14,336 patients who had received a diagnosis of CD (1964-2003) and 69,875 reference individuals matched for age, calendar year, sex and county. Patients were identified using the Swedish Hospital Discharge Registry. Follow-up began 1 year after study entry.

RESULTS:

CD was associated with an increased risk of any form of GN (hazard ratio (HR) = 1.64; 95% confidence intervals (CI) = 1.01-2.66; P = 0.046; 89 events), CGN (HR = 2.65; 95% CI = 1.34-5.24; P = 0.005; 39 events), dialysis (HR = 3.48; 95% CI = 2.26-5.37; P < 0.001; 102 positive events) and KT (HR = 3.15; 95% CI = 1.29-7.71; P = 0.012; 22 events).

CONCLUSION:

We suggest that immune characteristics associated with CD increase the risk of chronic renal disease. Individuals with CD may also be at a moderately increased risk of any form of GN.

Place, publisher, year, edition, pages
2006. Vol. 21, no 7, p. 1809-1815
Keywords [en]
Adolescent, Adult, Celiac Disease/*complications/*diagnosis, Child, Child; Preschool, Cohort Studies, Female, Glomerulonephritis/metabolism, Humans, Infant, Infant; Newborn, Kidney Diseases/*complications/*diagnosis, Kidney Transplantation, Male, Middle Aged, Proportional Hazards Models, Risk, Risk Factors
National Category
Medical and Health Sciences Clinical Medicine Urology and Nephrology
Research subject
Internal Medicine
Identifiers
URN: urn:nbn:se:oru:diva-3503DOI: 10.1093/ndt/gfl117PubMedID: 16574681OAI: oai:DiVA.org:oru-3503DiVA, id: diva2:137800
Available from: 2008-12-08 Created: 2008-12-08 Last updated: 2017-12-14Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16574681&dopt=Citation

Authority records BETA

Ludvigsson, Jonas F.Montgomery, Scott M.

Search in DiVA

By author/editor
Ludvigsson, Jonas F.Montgomery, Scott M.
By organisation
Department of Clinical Medicine
In the same journal
Nephrology, Dialysis and Transplantation
Medical and Health SciencesClinical MedicineUrology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 454 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf