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Relative telomere length in patients with late-onset Alzheimer's dementia or vascular dementia
Örebro University, School of Health and Medical Sciences.
2008 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 19, no 12, p. 1199-1202Article in journal (Refereed) Published
Abstract [en]

Telomeres generally shorten with age. An accelerated shortening of the telomeres has been linked to several age-related disorders. We hypothesized that the relative length of telomeres could discriminate between patients with late-onset Alzheimer's disease (AD) and vascular dementia (VaD). A quantitative real-time PCR method was used to calculate the relative telomere length in 76 age-matched and sex-matched, newly diagnosed late-onset AD or VaD patients recruited from our Memory Unit. No significant difference was found in the relative telomere length between AD and VaD cases neither in men (P=0.315) nor women (P=0.12). Thus, we could not confirm that the length of telomeres would predict which form of dementia, late-onset AD or VaD that develops.

Place, publisher, year, edition, pages
London: Lippincott Williams and Wilkins , 2008. Vol. 19, no 12, p. 1199-1202
Keywords [en]
Adolescent, Adult, Aged, Aged; 80 and over, Alzheimer Disease/*genetics, Base Sequence, Child, Child; Preschool, Dementia; Vascular/*genetics, Female, Humans, Male, Polymerase Chain Reaction/methods, Telomere/*genetics/metabolism
National Category
Medical and Health Sciences Clinical Medicine Neurology
Research subject
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-3511DOI: 10.1097/WNR.0b013e3283089220PubMedID: 18628664OAI: oai:DiVA.org:oru-3511DiVA, id: diva2:137808
Available from: 2008-12-08 Created: 2008-12-08 Last updated: 2017-12-14Bibliographically approved

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Hagnelius, Nils-OlofNilsson, Torbjörn K.

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CiteExportLink to record
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Citation style
  • apa
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Output format
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