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Microscopic colitis: a common and an easily overlooked cause of chronic diarrhoea
Örebro University, School of Health and Medical Sciences.
Örebro University, School of Health and Medical Sciences.
2008 (English)In: European journal of internal medicine, ISSN 0953-6205, E-ISSN 1879-0828, Vol. 19, no 3, p. 181-186Article in journal (Refereed) Published
Abstract [en]

Microscopic colitis, comprising collagenous colitis and lymphocytic colitis, is characterised clinically by chronic watery diarrhoea, a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscopic examination. The annual incidence of each disorder is 4–6/100,000 inhabitants, with a peak incidence in 60–70 year old individuals and a noticeable female predominance in collagenous colitis. The aetiology is unknown. Abdominal pain, weight loss, fatigue, and faecal incontinence are common symptoms in addition to chronic diarrhoea that impair the health-related quality of life of the patient. There is an association to other autoimmune disorders such as celiac disease, diabetes mellitus, thyroid disorders and arthritis. Budesonide is the best-documented short-term treatment, but the optimal long-term strategy needs further study. The long-term prognosis is good and the risk of complications including colonic cancer is low.

Place, publisher, year, edition, pages
Amsterdam: Elsevier , 2008. Vol. 19, no 3, p. 181-186
Keywords [en]
Chronic Disease, Clinical Protocols, Colitis; Microscopic/*complications/*diagnosis/therapy, Diarrhea/*etiology, Humans, Prognosis
National Category
Medical and Health Sciences Clinical Medicine
Research subject
Internal Medicine
Identifiers
URN: urn:nbn:se:oru:diva-3523DOI: 10.1016/j.ejim.2008.01.001PubMedID: 18395161OAI: oai:DiVA.org:oru-3523DiVA, id: diva2:137820
Available from: 2008-12-08 Created: 2008-12-08 Last updated: 2017-12-14Bibliographically approved

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Nyhlin, NilsBohr, JohanTysk, Curt

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