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Increased prevalence of HTLV-1 in patients with pulmonary tuberculosis coinfected with HIV, but not in HIV-negative patients with tuberculosis
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2008 (English)In: Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, E-ISSN 1944-7884, Vol. 48, no 5, p. 607-610Article in journal (Refereed) Published
Abstract [en]

Background: Few and inconclusive results have been presented regarding the influence of human T-lymphotropic virus 1 (HTLV-1) infection on the risk of acquiring tuberculosis (TB). Methods: In 1994-1997, we performed a prospective study on hospitalized adult patients with pulmonary TB in Guinea-Bissau and compared the clinical outcome in HIV-2 and HIV-negative patients. We determined the prevalence of HTLV-1 in all patients screened and diagnosed with TB in that study and compared the infection rate with a serosurvey of HTLV-1 in a population sample from a community-based study conducted at the same time and in the same city. Results: In the TB group, a total of 32 (11.4%) of 280 patients were positive for HTLV-1. This was significantly higher compared with the population-based group in which 74 (3.5%) of 2117 were HTLV-1 positive [crude odds ratio (OR) = 3.6; 95% confidence interval (CI) 2.2 to 5.6, P < 0.001]. However, in a logistic regression analysis controlling for age, gender, and HIV result, the difference was no longer significant (OR = 1.61; 95% CI 0.95 to 2.70, P = 0.074). In HIV-negative patients, no association was found between HTLV-1 and TB (OR = 1.18; 95% CI 0.48 to 2.89, P = 0.71), whereas a significant association was found in HIV-positive patients (OR = 2.41; 95% CI 1.26 to 4.61, P = 0.008). Conclusions: The immunosuppressive effect of HTLV-1 alone was not enough to increase the risk of TB in a highly endemic country, but HTLV-1 increased the risk of TB among HIV-infected individuals.

Place, publisher, year, edition, pages
Philadelphia, PA: Lippincott Williams & Wilkins , 2008. Vol. 48, no 5, p. 607-610
Keywords [en]
Adult, Female, HIV Infections/*complications/epidemiology/virology, HIV-1/isolation & purification, HIV-2/isolation & purification, HTLV-I Antibodies/*blood, HTLV-I Infections/complications/*epidemiology/virology, Human T-lymphotropic virus 1/isolation & purification, Humans, Logistic Models, Male, Middle Aged, Prevalence, Prospective Studies, Tuberculosis; Pulmonary/*complications/epidemiology
National Category
Medical and Health Sciences Microbiology in the medical area Microbiology in the medical area
Research subject
Microbiology
Identifiers
URN: urn:nbn:se:oru:diva-3544DOI: 10.1097/QAI.0b013e31817efb83PubMedID: 18645510OAI: oai:DiVA.org:oru-3544DiVA, id: diva2:137841
Available from: 2008-12-09 Created: 2008-12-09 Last updated: 2018-01-13Bibliographically approved

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Andersson, Sören

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