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Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort
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2008 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 17, no 1, p. 249-251Article in journal (Refereed) Published
Abstract [en]

Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.

Place, publisher, year, edition, pages
Baltimore: Waverly Press , 2008. Vol. 17, no 1, p. 249-251
Keyword [en]
Aged, Cohort Studies, Gene Expression Profiling/*methods, Humans, Immunoenzyme Techniques, Male, Prostate-Specific Antigen/blood, Prostatic Neoplasms/epidemiology/*metabolism/*mortality, Survival Rate, Tissue Array Analysis, Tumor Markers; Biological/*metabolism
National Category
Medical and Health Sciences Cancer and Oncology Urology and Nephrology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-3673DOI: 10.1158/1055-9965.EPI-07-0722PubMedID: 18199732OAI: oai:DiVA.org:oru-3673DiVA, id: diva2:137971
Available from: 2008-12-17 Created: 2008-12-17 Last updated: 2017-12-14Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18199732&dopt=Citation

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Fall, KatjaAndersson, Swen-OlofAndrén, OveHolmberg, LarsJohansson, Jan-Erik

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
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  • de-DE
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