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Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
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2008 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 40, no 10, p. 1153-1155Article in journal (Other academic) Published
Abstract [en]

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

Place, publisher, year, edition, pages
London: Nature Publishing Group , 2008. Vol. 40, no 10, p. 1153-1155
Keywords [en]
Aged, Chromosome Mapping, Chromosomes; Human; Pair 17/*genetics, Genetic Predisposition to Disease/*genetics, Haplotypes/*genetics, Hepatocyte Nuclear Factor 1-beta/*genetics, Humans, Linkage (Genetics), Male, Middle Aged, Polymorphism; Single Nucleotide/*genetics, Prostatic Neoplasms/*genetics/pathology, Risk Factors
National Category
Medical and Health Sciences Medical Genetics
Research subject
Medical Genetics
Identifiers
URN: urn:nbn:se:oru:diva-3676DOI: 10.1038/ng.214PubMedID: 18758462OAI: oai:DiVA.org:oru-3676DiVA, id: diva2:137974
Available from: 2008-12-17 Created: 2008-12-17 Last updated: 2018-01-13Bibliographically approved

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Johansson, Jan-Erik

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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  • modern-language-association-8th-edition
  • vancouver
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