To Örebro University

oru.seÖrebro University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Photodynamic therapy with topical 5-aminolevulinic acid for mycosis fungoides: clinical and histological response
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
2001 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 81, no 3, p. 184-188Article in journal (Refereed) Published
Abstract [en]

There is no curative treatment for mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma. The aim of this study was to investigate the response of single lesions to photodynamic therapy (PDT). The study included 10 plaque MF lesions and 2 tumour MF lesions from 10 patients. First, 20% 5-aminolevulinic acid was applied topically to the lesion and adjacent skin for 5-6 h. The lesion was then exposed to red light at around 630nm. Skin biopsies were taken before treatment, after clinical improvement and after clinical remission. The expression of CD3, CD4, CD7, CD8, CD1a, CD34, CD68, CD71, Ki-67, bcl-2 and p53 was studied immunohistochemically. There was complete clinical clearance in seven of nine plaque lesions. Neither tumour lesion responded to PDT. The biopsies confirmed a regression of the infiltrate after treatment. In the sparse remaining infiltrate a few CD4+ and CD8+ cells were found, most of which showed normal bcl-2. There were also fewer proliferating cells, illustrated by a decrease in Ki-67 and CD71. In conclusion, PDT has good clinical and histological effects in treating local plaque MF lesions.

Place, publisher, year, edition, pages
Taylor & Francis, 2001. Vol. 81, no 3, p. 184-188
Keywords [en]
A LA, Immunohistochemistry, Mycosis fungoides, Photodynamic therapy
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-78444DOI: 10.1080/000155501750376276PubMedID: 11558874Scopus ID: 2-s2.0-0034866146OAI: oai:DiVA.org:oru-78444DiVA, id: diva2:1380556
Available from: 2019-12-19 Created: 2019-12-19 Last updated: 2019-12-20Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Wiegleb Edström, Desirée

Search in DiVA

By author/editor
Wiegleb Edström, Desirée
In the same journal
Acta Dermato-Venereologica
Dermatology and Venereal Diseases

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 216 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf