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Phototherapy with ultraviolet radiation: a study of hormone parameters and psychological effects
Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden.
Psychiatry Section, Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden.
Betania Department of Dermatology, Stockholm, Sweden.
Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
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2010 (English)In: Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, E-ISSN 1468-3083, Vol. 24, no 4, p. 403-409Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND OBJECTIVES: Patients report well-being as they are treated with phototherapy. We investigated hormone parameters and psychological well-being after phototherapy in a placebo-controlled study.

METHODS: A total of 77 patients with dermatological conditions and 22 healthy volunteers were divided into four groups. The patients received phototherapy either on the whole body or only on hands and/or feet. The volunteers were given either whole-body phototherapy or placebo light. Serum or plasma samples were analysed for cortisol, calcium, magnesium, phosphate, TSH, T(4), T(3) and 25-hydroxyvitamin D, and urine samples for cortisol. Patients and volunteers answered a questionnaire before and 6 weeks after phototherapy/placebo light. Psychiatric ratings were performed according to the Comprehensive Psychopathological Self-rating Scale for Affective Syndromes, a self-report version of which has been transformed to correspond to the Montgomery-Asberg Depression Rating Scale (MADRS).

RESULTS: In the patients who received whole-body irradiation, we observed a significant improvement in both MADRS score and cognitive-symptom score after the completion of phototherapy. We also observed a significantly higher level of 25-hydroxyvitamin D after phototherapy, but no difference in the other hormone parameters.

CONCLUSION: Whole-body phototherapy of patients with dermatological conditions results in improved well-being and significantly higher levels of 25-hydroxyvitamin D in serum.

Place, publisher, year, edition, pages
Blackwell Publishing, 2010. Vol. 24, no 4, p. 403-409
Keywords [en]
phototherapy, questionnaire, ultraviolet irradiation, vitamin D, well‐being
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-78437DOI: 10.1111/j.1468-3083.2009.03423.xISI: 000275206300005PubMedID: 19778361Scopus ID: 2-s2.0-77749327960OAI: oai:DiVA.org:oru-78437DiVA, id: diva2:1380565
Note

Funding Agencies: Edvard Welander Foundation and Finsen Foundation 

Available from: 2019-12-19 Created: 2019-12-19 Last updated: 2020-01-13Bibliographically approved

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Wiegleb Edström, Desirée

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