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Alternative methods of insulin sensitivity assessment in obese children and adolescents
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-6328-5494
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2008 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 31, no 4, p. 802-804Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE—To validate fasting indexes against minimal model analysis (MMOD) of the frequently sampled intravenous glucose tolerance test (FSIVGTT) in an obese pediatric population.

RESEARCH DESIGN AND METHODS—FSIVGTT-MMOD results were compared with homeostasis model assessment of insulin resistance (HOMA-IR) and fasting insulin with the sample stratified by sex, puberty, and sensitivity index (Si) median in 191 children (82 males and 109 females, 13.9 ± 2.9 years of age, BMI 36.9 ± 6.2 kg/m2, BMI SD score 6.1 ± 1.6).

RESULTS—Across pubertal groups, correlation coefficients between Si and HOMA-IR ranged from −0.43 to −0.78 in males and from −0.53 to −0.57 in females (age and BMI adjusted, P < 0.05 in all instances). Similar results were seen for fasting insulin. In females, the relationship was significantly weaker in more-insulin-resistant subjects.

CONCLUSIONS—The validity of fasting indexes in explaining Si was sex dependent, varied with pubertal stage, and in females was influenced by degree of insulin sensitivity. In obese pediatric populations, we generally discourage the use of fasting indexes, although the validity varies within subgroups.

Place, publisher, year, edition, pages
Alexandria, Va.: American Diabetes Association , 2008. Vol. 31, no 4, p. 802-804
Keywords [en]
Absorptiometry; Photon, Adolescent, Adult, Blood Glucose/*metabolism, Child, Child; Preschool, Female, Glucose Tolerance Test, Humans, Insulin/*blood, Insulin Resistance, Male, Obesity/*blood, Overweight/*blood
National Category
Medical and Health Sciences Clinical Medicine Endocrinology and Diabetes
Research subject
Internal Medicine
Identifiers
URN: urn:nbn:se:oru:diva-3771DOI: 10.2337/dc07-1655PubMedID: 18202247OAI: oai:DiVA.org:oru-3771DiVA, id: diva2:138069
Available from: 2009-01-05 Created: 2009-01-05 Last updated: 2017-12-14Bibliographically approved

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Montgomery, Scott M.

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