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Cognitive function in children and subsequent type 2 diabetes
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-6328-5494
2008 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 31, no 3, p. 514-516Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To assess whether a diagnosis of type 2 diabetes by age 42 years is associated with prior cognitive deficits in childhood.

RESEARCH DESIGN AND METHODS: Logistic regression estimated type 2 diabetes risk among 9,113 members of the 1958 British birth cohort of the National Child Development Study (NCDS). Associations with type 2 diabetes were estimated for general ability and reading comprehension assessments at age 11 years, modeled using SD units. Adjustment was for markers of early-life exposures, social and material family characteristics, sex, and disability, with further adjustment for BMI at age 7 years.

RESULTS: Adjusted odds ratios (95% CIs) for type 2 diabetes (n = 69) are 0.67 (0.51-0.87) for general ability and 0.58 (0.44-0.77) for reading comprehension. Neither additional adjustment for BMI, nor limiting the definition of type 2 diabetes to onset after age 33 years altered the associations substantially.

CONCLUSIONS: Impaired cognitive function may precede clinical onset of type 2 diabetes.

Place, publisher, year, edition, pages
Alexandria, Va.: American Diabetes Association , 2008. Vol. 31, no 3, p. 514-516
Keywords [en]
Adolescent, Adult, Child, Cognition Disorders/*complications, Cohort Studies, Diabetes Mellitus; Type 2/diagnosis/*epidemiology/etiology, Female, Great Britain/epidemiology, Humans, Logistic Models, Male, Pregnancy, Risk Factors
National Category
Medical and Health Sciences Clinical Medicine
Research subject
Internal Medicine
Identifiers
URN: urn:nbn:se:oru:diva-3772DOI: 10.2337/dc07-1399PubMedID: 18083794OAI: oai:DiVA.org:oru-3772DiVA, id: diva2:138070
Available from: 2009-01-05 Created: 2009-01-05 Last updated: 2017-12-14Bibliographically approved

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Montgomery, Scott M.

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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Language
  • de-DE
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  • Other locale
More languages
Output format
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