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Differential regulation of IgG subclasses and IgE antimalarial antibody responses in complicated and uncomplicated Plasmodium falciparum malaria
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-6328-5494
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2007 (English)In: Parasite immunology (Print), ISSN 0141-9838, E-ISSN 1365-3024, Vol. 29, no 9, p. 475-483Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to assess the immunoglobulin (Ig)-subclass distribution of antimalarial antibody responses in 110 and 169 Thai patients with complicated and uncomplicated Plasmodium falciparum malaria, respectively. Antimalarial plasma IgG subclasses and IgE antibody levels against a crude malaria blood stages, and antigen preparation were determined using enzyme-linked immunosorbent assay (ELISA). On admission, the levels of anti-P. falciparum IgG1, IgG2 and IgG3 were significantly lower in patients with complicated malaria than uncomplicated malaria (IgG1, P < 0.0001; IgG2, P < 0.0001; IgG3, P < 0.0001). The levels of antimalarial IgE were slightly lower, but not statistically significant (P = 0.389) in the complicated malaria. After adjusting all antibody levels and age, anti-P. falciparum IgG3 levels remained significantly associated with complicated malaria. None of the other antibody concentrations showed statistically significant associations with complicated malaria. The anti-P. falciparum IgG3 levels were related to the IgG1 as well as IgG2 levels. A correlation between anti-P. falciparum IgG2 and IgE was observed in the complicated malaria group, and this may indicate their roles in the severity of disease. Our data suggest that anti-P. falciparum IgG3 is associated with a reduced risk of complicated malaria and that antimalarial Ig-subclasses are differently regulated in patients with complicated and uncomplicated malaria.

Place, publisher, year, edition, pages
Oxford: Blackwell Science , 2007. Vol. 29, no 9, p. 475-483
Keywords [en]
Adolescent, Adult, Aged, Animals, Antibodies; Protozoan/*blood/immunology, Antigens; Protozoan/immunology, Female, Humans, Immunoglobulin E/*blood/immunology, Immunoglobulin G/*blood/immunology, Malaria; Cerebral/immunology, Malaria; Falciparum/*immunology/parasitology, Male, Middle Aged, Plasmodium falciparum/*immunology, Thailand
National Category
Medical and Health Sciences Immunology in the medical area
Research subject
Immunology
Identifiers
URN: urn:nbn:se:oru:diva-3779DOI: 10.1111/j.1365-3024.2007.00965.xPubMedID: 17727571OAI: oai:DiVA.org:oru-3779DiVA, id: diva2:138077
Available from: 2009-01-05 Created: 2009-01-05 Last updated: 2018-01-13Bibliographically approved

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Montgomery, Scott M.

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