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Perinatal events and the risk of developing primary sclerosing cholangitis
Örebro University, Department of Clinical Medicine.ORCID iD: 0000-0001-6328-5494
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2006 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 12, no 37, p. 6037-6040Article in journal (Refereed) Published
Abstract [en]

AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life.

METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC.

RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including infections or medication during pregnancy for the mothers or postpartum for the children. Vaginal bleeding and peripheral oedema showed associations with PSC, with matched odds ratios of 5.70 (95% CI, 1.13-28.83) and 2.28 (95% CI, 1.04-5.03), respectively.

 

CONCLUSION: The associations of vaginal bleeding and oedema with subsequent PSC cannot readily be explained, so our findings do not strongly support the hypothesis of a significant role of perinatal events as a risk for the development of PSC later in life.

Place, publisher, year, edition, pages
2006. Vol. 12, no 37, p. 6037-6040
Keywords [en]
Adult, Breast Feeding, Cholangitis, Sclerosing/*etiology/physiopathology, Edema/complications/physiopathology, Female, Humans, Labor, Obstetric/physiology, Logistic Models, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Retrospective Studies, Risk Factors, Uterine Hemorrhage/complications/physiopathology
National Category
Medical and Health Sciences Clinical Medicine Gastroenterology and Hepatology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-3788PubMedID: 17009405OAI: oai:DiVA.org:oru-3788DiVA, id: diva2:138086
Available from: 2009-01-05 Created: 2009-01-05 Last updated: 2017-12-14Bibliographically approved

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PubMedhttp://www.wjgnet.com/1007-9327/12/6037.asp

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Montgomery, Scott M.

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