oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Skeletal muscle morphology in patients with restless legs syndrome
Örebro University, Department of Clinical Medicine. Dalarna University, Falun, Sweden. (RISPA)
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (RISPA- MEP-RG)ORCID iD: 0000-0002-9831-0896
Avesta Hospital, Avesta, Sweden.
Örebro University, Department of Clinical Medicine.
2007 (English)In: European Neurology, ISSN 0014-3022, E-ISSN 1421-9913, Vol. 58, no 3, p. 133-137Article in journal (Refereed) Published
Abstract [en]

AIM: The aim of the study was to assess the cellular and structural properties of skeletal muscle in restless legs syndrome (RLS).

METHOD: Twenty patients and 16 controls were included. Aerobic performance was assessed using a submaximal test. On muscle biopsies taken from the tibialis anterior, fiber distribution and fiber area were analyzed together with parameters surveying the microvascularization, especially the tortuosity, which is expressed as a percent of muscle fiber perimeter in contact with the wall of the microvessel, length of capillary/perimeter of fiber (LC/PF) index.

RESULTS: The RLS group had significantly lower predicted maximal oxygen uptake (p = 0.01) and significantly higher LC/PF index (p = 0.01) compared to the controls.

CONCLUSION: The higher capillary tortuosity in RLS patients indicates the occurrence of significant remodeling in capillary geometry in RLS.

Place, publisher, year, edition, pages
2007. Vol. 58, no 3, p. 133-137
National Category
Sport and Fitness Sciences Social Sciences Interdisciplinary
Research subject
Sports Science
Identifiers
URN: urn:nbn:se:oru:diva-4035DOI: 10.1159/000104712ISI: 000249536800002PubMedID: 17622717OAI: oai:DiVA.org:oru-4035DiVA, id: diva2:138334
Available from: 2007-09-20 Created: 2007-09-20 Last updated: 2018-01-13Bibliographically approved
In thesis
1. Skeletal muscle in Restless legs syndrome (RLS) and Obstructive sleep apnoea syndrome (OSAS)
Open this publication in new window or tab >>Skeletal muscle in Restless legs syndrome (RLS) and Obstructive sleep apnoea syndrome (OSAS)
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Restless legs syndrome (RLS) and Obstructive sleep apnoea syndrome (OSAS) are two sleep disorders that affect daily life with symptoms such as sleepiness and fatigue. It was therefore hypothesised that the skeletal muscle could be affected as symptoms from skeletal muscle are common. The overall aim of the thesis was to investigate aerobic capacity and structure of skeletal muscle in patients with OSAS and RLS and an age matched control group to provide information regarding the underlying mechanisms. The specific aims were to investigate muscle fibre composition, capillary network, capillary proliferation and sings of local inflammation in musculus tibialis anterior of RLS and OSAS.OSAS and RLS patients had a significantly lower predicted VO2 max expressed in ml/min/kg compared with the control group and in the OSAS group apnoes-hyponea index (AHI) was inversely correlated to maximal oxygen uptake Fibre type composition and muscle fibre cross sectional area in the tibialis anterior muscle was equal in all groups with a predominant proportion of slow type I fibres and a smaller fibre area in slow type I fibres compared to fast type II fibres. The distribution of fast fibres (I/IIA, IIA) did not differ except for the group IIX and IIA/IIX where OSAS and RLS had a significantly higher percentage. OSAS patients had a significantly higher number of capillaries per fibre (CAF) for slow type I fibres and CAF per fibre area (CAFA) for fast type II fibres. CFPE- index (capillary to fibre perimeter exchange) and LC/PF-index (length of capillary/perimeter of fibre) were higher in both patient groups. Vascular endothelial growth factor (VEGF) and proliferating endothelial cells were analysed by double-immunofluorescence staining and were presented to a greater extent in the patient groups compared with the healthy controls. Based on normal amounts of T-cells and macrophages in the histological picture it was also demonstrated that local inflammation was not present in the tibialis anterior muscle of RLS and OSAS whish was also supported by the absence of expression of major histocompatibility complex class I molecules (MHC class I) on the surface of the tibialis anterior muscle fibres.In conclusion, the low predicted VO2 max together with higher percentage of type IIX and IIA/IIX muscle fibres indicates a low central capacity in the patient groups. The increased capillary network and the absence of inflammation indicate the occurrence of local hypoxia in tibialis anterior muscle in patients OSAS and RLS.

Place, publisher, year, edition, pages
Örebro: Örebro university, 2009. p. 61
Series
Örebro Studies in Sport Sciences, ISSN 1654-7535 ; 3
Keywords
RLS, OSAS, aerobic capacity, skeletal muscle fibers, capillary, VEGF
National Category
Dentistry Sport and Fitness Sciences
Research subject
Sports Science
Identifiers
urn:nbn:se:oru:diva-6245 (URN)978-91-7668-661-4 (ISBN)
Public defence
2009-05-08, Hörsal P2, Prismahuset, Örebro Universitet, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2009-04-14 Created: 2009-04-14 Last updated: 2017-10-18Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Wåhlin Larsson, BrittaKadi, FawziPiehl Aulin, Karin

Search in DiVA

By author/editor
Wåhlin Larsson, BrittaKadi, FawziPiehl Aulin, Karin
By organisation
Department of Clinical MedicineSchool of Health and Medical Sciences, Örebro University, Sweden
In the same journal
European Neurology
Sport and Fitness SciencesSocial Sciences Interdisciplinary

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 569 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf