oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Hydrogen Abstraction from Deoxyribose by a Neighbouring Uracil-5-yl Radical
Örebro University, Department of Natural Sciences. (Biophysical Chemistry)
2007 (English)In: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 9, p. 5975-5979Article in journal (Refereed) Published
Abstract [en]

Hydrogen abstraction from the C1 and C2 positions of deoxyadenosine by a neighbouring uracil-5-yl radical in the 5-AU-3 DNA sequence is explored using DFT. This hydrogen abstraction is the first step in a sequence leading to single or double strand break in DNA. The uracil-5-yl radical can be the result of photolysis or low-energy electron (LEE) attachment. If the radical is produced by photolysis the neighbouring adenine will become a cation radical and if it is produced by LEE the adenine will remain neutral. The hydrogen abstraction reactions for both cases were investigated. It is concluded that it is possible for the uracil-5-yl to abstract hydrogen from C1 and C2. When adenine is neutral there is a preference for the C1 site and when the adenine is a radical cation the C2 site is the preferred. If adenine is positively charged, the rate-limiting step when abstracting hydrogen from C1 is the formation of an intermediate crosslink between uracil and adenine. This crosslink might be avoided in dsDNA, making C1 the preferred site for abstraction.

Place, publisher, year, edition, pages
Royal Society of Chemistry , 2007. Vol. 9, p. 5975-5979
Keywords [en]
Theoretical chemistry
National Category
Natural Sciences Chemical Sciences Physical Chemistry
Research subject
Physical Chemistry; Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-4306DOI: 10.1039/b711083aOAI: oai:DiVA.org:oru-4306DiVA, id: diva2:138605
Available from: 2007-12-17 Created: 2007-12-17 Last updated: 2017-12-14Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Eriksson, Leif A.

Search in DiVA

By author/editor
Eriksson, Leif A.
By organisation
Department of Natural Sciences
In the same journal
Physical Chemistry, Chemical Physics - PCCP
Natural SciencesChemical SciencesPhysical Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 33 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf