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Differentiation and survival influences of growth factors in human neuroblastoma
Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden.
Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden.
Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden.ORCID iD: 0000-0001-8889-5803
Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden.
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1995 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 31A, no 4, p. 453-458Article in journal (Refereed) Published
Abstract [en]

Human neuroblastoma cell lines are established from high-stage, highly malignant tumours. Despite this and the fact that these tumours are arrested at an early, immature stage, many cell lines have the capacity to undergo neuronal differentiation under proper growth conditions. One such cell line is the noradrenergic SH-SY5Y cell line. These cells can be induced to mature by a variety of modalities, resulting in different mature phenotypes. The use of this cell system as a model to study the stem cell character of neuroblastoma is reviewed and discussed. In particular, we focus on growth factor dependencies in the SH-SY5Y system, and compare that to the normal situation, i.e. growth factor control of sympathetic neuronal and neuroendocrine differentiation during human and rat embryogenesis.

Place, publisher, year, edition, pages
Elsevier, 1995. Vol. 31A, no 4, p. 453-458
Keywords [en]
neuroblastoma, neurotrophins, insulin-like growth factors, fibroblast growth factors, differentiation, apoptosis, sympathetic nervous system, sympathoadrenal
National Category
Medical and Health Sciences Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-79054DOI: 10.1016/0959-8049(95)00033-fISI: A1995QY18000007PubMedID: 7576944Scopus ID: 2-s2.0-0029033940OAI: oai:DiVA.org:oru-79054DiVA, id: diva2:1386267
Available from: 2013-10-20 Created: 2020-01-17 Last updated: 2020-01-27Bibliographically approved

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